Manganese Supplements a Crook Idea
An essential element but easily overdosed causing Prion Disease and Manganism
I started looking at Manganese Toxicity many years ago when working for the Alumina Widows and Workers Action Group, looking at known exposures at Alumina refineries and Bauxite mines. This included welders and workers around them exposed to inhaled Manganese.
A recent thread on X prompted me to outline a few facts here to discourage people from taking Manganese supplements based on false claims of need or benefit.
Found a nice illustration of Manganism.1 This disease was identified in 1837.2
No evidence of Manganese Deficiency
Experts in the field3 state quite clearly "No Case of Manganese Deficiency in Humans has been identified."
The lungs and gastrointestinal tract absorb some manganese, but the relative amounts absorbed from each site are not known. Homeostatic mechanisms limit the absorption of manganese from the gastrointestinal tract.
Elimination of manganese occurs primarily by excretion into the bile.
Animal studies indicate that manganese is an essential co-factor for enzymes, such as hexokinase, superoxide dismutase, and xanthine oxidase.
However, no case of manganese deficiency in humans has been identified.
No evidence has beeen found for age-related Manganese deficency in relation to Prostate Cancer.4
Manganese Hazard from Tea
Japanese researchers measured Manganese content of dry Tea leaves and brewed Tea.5
Manganese Enhances Coronavirus Infection
Researchers in Texas reported that Manganese is the preferred element used by The Severe Acute Respiratory Syndrome Coronavirus Nonstructural protein 15 (Nsp15) Protein as a cofactor.6
Nsp15 is a uridylate-specific endoribonuclease. The researchers used Escherichia coli bacteria to express it so they could study how useful it is in Bioweapon development.7
Manganese is a proven Neurotoxin
You might like to read 2,450 papers found8 by searching PubMed for “Manganese Neurotoxicity”.
Or perhaps 1,960 papers found on PubMed by searching Manganism.9
Manganese and Amyloid Prion Disease
Searching PubMed for “Manganese Prion” finds 118 peer-reviewed papers.10
Nice 2019 article looked at mechanism.11
In cultured dopaminergic neuronal cells stably expressing wild-type human αSyn, misfolded αSyn was secreted through exosomes into the extracellular medium upon Mn2+ exposure.
These exosomes were endocytosed through caveolae into primary microglial cells, thereby mounting neuroinflammatory responses. Furthermore, Mn2+-elicited exosomes exerted a neurotoxic effect in a human dopaminergic neuronal model (LUHMES cells). Moreover, bimolecular fluorescence complementation (BiFC) analysis revealed that Mn2+ accelerated the cell-to-cell transmission of αSyn, resulting in dopaminergic neurotoxicity in a mouse model of Mn2+ exposure.
Manganese in my other articles
Mentioned in passing Manganese involved as promoter of Endotoxin changes in expression of HMOX1.12
Research at Mitochondrial level links Pulmonary Hypertension to Manganese Superoxide Dismutase (SOD2).13
Disruption of SOD2 is involved in Jab Narcolepsy.14
Manganese Synergy with Endotoxin Poisoning
Nice article by Gu and coworkers15 presented this scheme.
Enhancement of lipopolysaccharide-induced innate immune gene expression by Mn2+ varies between 10 % and 900 %.
Mn2+ exerted its ability to potentiate LPS-induced innate immune gene expression regardless of slight pH changes. Importantly, we found that Mn2+ potentiates lipopolysaccharide-induced immune responses independent of TLR4 but partially relies on cGAS-STING pathway.
Further in vivo study showed that colloidal Mn2+ salt (Mn jelly [MnJ]) pretreatment exacerbated lipopolysaccharide-induced septic shock and mice death.
Manganese Poisoning via TLR2,16 TLR517 and TLR9.18
Manganese with Copper and Zinc
A 2007 review.19
I had more about Manganese on Facebook before the evil Zuckerberg and his wife locked me out for money. Might expand later if there is subscriber interest.
Kaycie D. https://www.facebook.com/eycn.eu/posts/manganese-can-lead-to-manganism-a-toxic-state-causing-hallucinations-and-violenc/10157737171138609/
https://en.wikipedia.org/wiki/Manganism
D G Barceloux. 1999. Manganese. J Toxicol Clin Toxicol 37(2):293-307. doi: 10.1081/clt-100102427. https://www.tandfonline.com/doi/full/10.1081/CLT-100102427
V. Zaichick, S. Zaichick. DIETARY INTAKE OF MINERALS AND PROSTATE CANCER: INSIGHTS INTO PROBLEM BASED ON THE CHEMICAL ELEMENT CONTENTS IN THE PROSTATE GLAND. https://www.jarlife.net/1169-dietary-intake-of-minerals-and-prostate-cancer-insights-into-problem-based-on-the-chemical-element-contents-in-the-prostate-gland.html
F Matsushima, S Meshitsuka and T Nose. 1993. Nihon Eiseigaku Zasshi. 48(4):864-72
Kanchan Bhardwaj, Linda Guarino, C. Cheng Kao. 2004. The Severe Acute Respiratory Syndrome Coronavirus Nsp15 Protein Is an Endoribonuclease That Prefers Manganese as a Cofactor. https://journals.asm.org/doi/epub/10.1128/jvi.78.22.12218-12224.2004
Pfizer used Synthetic Life derived from US Bioweapons research for its mRNA trials
If you want to turn Coronavirus into a more lethal weapon, you need to make sure its entry into Human cells is enhanced.
https://pubmed.ncbi.nlm.nih.gov/?term=manganese+neurotoxicity
https://pubmed.ncbi.nlm.nih.gov/?term=manganism
https://pubmed.ncbi.nlm.nih.gov/?term=Manganese+prion
Dilshan S. Harischandra, Dharmin Rokad, Matthew L. Neal, Shivani Ghaisas, Sireesha Manne, Souvarish Sarkar, Nikhil Panicker, Gary Zenitsky, Huajun Jin, Mechelle Lewis, Xuemei Huang, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy. 2019. Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein. Science Signaling. 12:eaau4543 https://www.science.org/doi/10.1126/scisignal.aau4543
Mast Cell Activation Syndrome caused by Endotoxin
This subject came up on X during my discussion of Myalgic Encephalomyelitis or Chronic Fatigue Syndrome. Clearly the two are interrelated.
Endotoxin in Jabs causes Pulmonary Hypertension
I was prompted to start this article by a tweet from British lawyer Peter Todd, who pointed us toward a recent paper by Robert Sullivan and coworkers reporting 2 cases of Pulmonary Hypertension after Pfizer jabbing.
Yanchao Gu, Jingjing Tang, Fuhua Zhang, Yichen Qu, Min Zhao, Mengyuan Li, Zhen Xie, Xiao Wang, Li Song, Zhengfan Jiang, Yao Wang, Xihui Shen, Lei Xu. 2023. Manganese potentiates lipopolysaccharide-induced innate immune responses and septic shock. https://www.sciencedirect.com/science/article/abs/pii/S0141813023000764
TLR2 Diseases caused by Bacterial Lipoprotein in Jabs
Recently I reported on Foster Coulson company Qu Biologics that has patented Jabs containing extracts of killed Bacteria. I covered some of the harms caused by hitting your TLR5 and now I focus on TLR2 induced harms which originate from part of the Bacterial Cell Wall known as Lipoprotein or Lipopeptide.
TLR5 Diseases from deliberate use of Bacterial Flagellin in Jabs
In previous posts I have mentioned the Human Toll-like Receptor 5 (TLR5) that reacts to the “dangly bits” emanating from Bacteria, in contrast to the Endotoxin (Lipolysaccharide) fragments of the cell wall. In this figure we see that TLR5 and TLR4 are on the surface of your cells, whereas DNA contamination of the jabs triggers reactions via TLR9 and dou…
TLR9 Diseases from Endotoxin and DNA in Jabs
Previously I have covered the impact of Endotoxin, either as a contaminant, or deliberately added to injections on a range of Toll-Like Receptors (TLRs).
Scott P. Leach, M D Salman and Dwayne Hamar. 2007. Trace elements and prion diseases: a review of the interactions of copper, manganese and zinc with the prion protein. https://www.cambridge.org/core/journals/animal-health-research-reviews/article/abs/trace-elements-and-prion-diseases-a-review-of-the-interactions-of-copper-manganese-and-zinc-with-the-prion-protein/04F06964BF8BDC657758AF4212402CEC
Oops ! I am a tea drinker, mostly black China and Ceylon, and Earl Grey. Thankfully I seldom take mineral supplements, apart from a bit of magnesium at times.
Thanks for this article. I wonder if it is really necessary to take supplements at all, unless one is sick and cannot get enough from food. After all, people 200 years ago HAD no supplements. They did not live as long, maybe, but they probably also had no such ailments as people nowadays have. What good is it to live to 100 and be unaware for years about life?