Narcolepsy after Pfizer mRNA Jabs

What caused the explosion of Narcolepsy cases observed and some say anticipated, after the Pfizer mRNA jabs? Endotoxin is the culprit.

Narcolepsy associated with jabbing

A useful 2018 review

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describes the suffering and what is known about possible causes of Narcolepsy:

Narcolepsy is a debilitating neurological disorder characterized by uncontrollable rapid eye movement attacks, which are not preceded by a non-rapid eye movement stage as occurs normally. The disease classically manifests as excessive daytime sleepiness, which may be accompanied by disrupted nocturnal sleep, sleep paralysis, hallucinations and obesity. Narcoleptic patients are believed to suffer from selective destruction of Hypothalamic neurons, which are responsible for producing Orexin, also termed Hypocretin (HCRT), a neurotransmitter involved in regulating sleep-wake states.

Narcolepsy or Hypersomnia (Photo credit)

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has been strongly associated with some seasonal Influenza jabs and numerous publications are cited in a 2021 US government review.

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Numerous factors are probably involved, including individual genetic susceptibility and jab Adjuvants.

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In America the CDC anticipated that mass jabbing with hastily contrived Covid19 treatments might trigger numerous Adverse Events, some of which were actively monotored. Narcolepsy, also known as Cataplexy, or Hypersomnia, was one of these.

Here we see a Table of early results from a CDC meeting in February 2021. Note the CDC had no entry for “Adjusted expected events in the risk interval” because Narcolepsy is normally very rare.

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Cases of Narcolepsy continued to grow, so by April 2021, Pfizer reported 4 cases of Narcolepsy.

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By 16 June 2021, a surge of Covid19 induced Narcolepsy and Hypersomnia was evident with 57 cases in UK reported to the Yellow Cards database of Adverse Events after Pfizer jabs.

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By April 2022, Pfizer reported

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the following cases numbers:

Hypersomnia 1,725

Narcolepsy 79

Cataplexy 15

New Zealand government flagged Narcolepsy after Pfizer jabs as a concern.

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Endotoxin in mRNA jabs a missing Narcolepsy Link?

Given that Endotoxin in the mRNA jabs is linked to numerous Autoimmune diseases, including those affecting the Brain and Central Nervous System

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, I am interested in exploring a possible cause of Narcolepsy that seems to have been overlooked.

Guillain-Barré syndrome, possibly arising from similar assault on the Brain to Narcolepsy, has been associated with Gram-Negative bacterial infection with Campylobacter jejuni

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and Mycoplasma pneumoniae. The Endotoxin does the damage and focus has been on the polysaccharide with explanations at molecular mimicry level. Those from Campylobacter jejuni are associated with Guillain-Barre Syndrome Patients' Gangliosides.

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Bell’s Palsy after nasal Influenza treatment led to cancellation

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of the product which used Escherichia coli Endotoxin as Adjuvant.

Hypersomnia, i.e. Narcolepsy has been directly linked to Endotoxin.

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Narcolepsy is often accompanied by increased feelings of Anxiety and Fear, and this has been produced experimentally with Endotoxin in animals.

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Tragically, a Coroner found that a young nurse who suffered Narcolepsy and killed herself, was most likely a victim of Pandemrix jab, Mandated by her employer.

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Endotoxin is known to bind to broadly reactive Influenza Antibodies which also bind to other proteins including Insulin and double-stranded DNA (dsDNA, another known contaminant in the Pfizer jabs).

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Mechanism of Narcolepsy

Orexin (Hypocretin) is a key Neuropeptide involved in Narcolepsy.

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Interestingly, G-protein-coupled Orexin receptors are found in the Pineal Gland and affect Melatonin secretion.

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Cross-reactive Antibodies to Hypocretin receptor 2 were found in Pandemrix jabbees.

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In April 2023, the UK government admitted that Hypocretin = Orexin is the key to Narcolepsy caused by Pandemrix, but still falselly claimed the mechanism is unknown.

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The following figure shows how Endotoxin (LPS) impacts on the Sleep cycle by blocking the balance of Orexin and Pineal Melatonin.

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The Figure caption by Anderson and coworkers is as follows:

Gut dysbiosis/permeability increase circulating LPS and exosomal HMGB1, leading to TLR activation in microglia and the induction of iNOS and superoxide. This leads to the formation of ONOO^-, which is a major inducer of aSMase and ceramide. Ceramide has negative impacts on mitochondria functioning, both directly and via the inhibition of orexin and melatonin. Orexin, melatonin, and butyrate disinhibit PDC, leading to an increased conversion of pyruvate to acetyl-CoA, which is the necessary co-substrate for AANAT and the initiation of the mitochondria melatonergic pathway. Increased mitochondria melatonin promotes SOD2, sirtuin-3, and oxidative phosphorylation. By decreasing cellular 14–3-3, ceramide may also inhibit the stabilization of AANAT, thereby preventing the initiation of the melatonergic pathway. Ceramide also increases metabolic syndrome, lipid dysregulation, and gluconeogenesis, all of which are more evident in MS. Gut dysbiosis/permeability have reciprocal interactions with stress, cytokines, and oxidative stress, which can all increase IDO and TDO, leading to kynurenine, which activates the AhR and increases CYP1b1, leading to the backward conversion of melatonin to NAS. Gut dysbiosis/permeability lowers butyrate levels, thereby decreasing butyrate’s suppression of ceramide. Butyrate drives the conversion of ceramide to glucosylceramide and the MS-protective gangliosides. The decrease in butyrate attenuates its inhibition of glia and immune cell reactivity, likely mediated via butyrate regulation of the mitochondrial melatonergic pathway. Abbreviations: AANAT: aralkylamine N-acetyltransferase; AhR: aryl hydrocarbon receptor; aSMase: acid sphingomyelinase; ASMT: N-acetylserotonin O-methyltransferase; CYP: cytochrome P450; HMGB: high-mobility group box; IDO: indoleamine 2,3-dioxygenase; iNOS: inducible nitric oxide; synthase; LPS: lipopolysaccharide; NAS: N-acetylserotonin; NOX/NADPH oxidase: nicotinamide adenine dinucleotide phosphate oxidase; ONOO-: peroxynitrite; PDC: pyruvate dehydrogenase complex; PDK: pyruvate dehydrogenase kinase; PEPT: peptide transporter; SOD2: manganese superoxide dismutase; TDO: tryptophan 2,3-dioxygenase; TLR: toll-like receptor.

Conclusion

Endotoxin in mRNA jabs arising from the use of E. coli is the cause of Narcolepsy via the scheme above.

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5. Shimburuko T. 13 Feb 2021. https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-02/28-03-01/05-covid-Shimabukuro.pdf

6. https://phmpt.org/wp-content/uploads/2021/11/5.3.6-postmarketing-experience.pdf

7. Classen JB. COVID-19 Vaccine Associated Parkinson’s Disease, A Prion Disease Signal in the UK Yellow Card Adverse Event Database. J Med - Clin Res & Rev. 2021; 5(7): 1-6.

8. APPENDIX 2.1 Cumulative Number of Case Reports (Serious and Non-Serious, Medically Confirmed and Non Medically-Confirmed) from Post-Marketing Data Sources, Overall, by Sex, Country, Age Groups and in Special Populations and Summary Tabulation by Preferred Term and MedDRA System Organ Class BNT162B2 - ALL Reporting Period: Through 15-APR-2022

9. Medsafe New Zealand. https://www.health.govt.nz/system/files/documents/information-release/h202106950-_response.pdf

10. Parkinson's Disease after Pfizer jabs most likely due to Endotoxin in every vial

11. Fatigue, Headache, Muscle Pain, Fever and Chills after Pfizer Jabs match Endotoxin Effects

12. Aspinall GO, et al. 1994. Lipopolysaccharides from Campylobacter jejuni associated with Guillain-Barré syndrome patients mimic human gangliosides in structure. https://journals.asm.org/doi/10.1128/iai.62.5.2122-2125.1994

13. Guillain-Barré Syndrome expected from Pfizer Endotoxins

14. Couch RB. 2004. Nasal vaccination, Escherichia coli enterotoxin, and Bell's palsy. https://www.nejm.org/doi/pdf/10.1056/NEJMp048006

15. Zakaria R, et al. 2017. Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of Alzheimer’s Disease. https://pubmed.ncbi.nlm.nih.gov/28406691/

16. Pugh CR, et al. 1998. Selective Effects of Peripheral Lipopolysaccharide Administration on Contextual and Auditory-Cue Fear Conditioning. https://www.sciencedirect.com/science/article/abs/pii/S0889159198905244

17. https://www.theguardian.com/uk-news/2016/aug/11/swine-flu-jab-most-likely-led-to-narcolepsy-in-nurse-who-killed-herself-coroner

18. Labombarde JC, et al. Induction of broadly reactive influenza antibodies increases susceptibility to autoimmunity. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00215-7

19. Autoimmune Diseases caused by Endotoxin in mRNA Jabs include Myocarditis, Pericarditis Lupus

20. Ahmed SS. 2015. Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2. https://www.science.org/doi/10.1126/scitranslmed.aab2354

21. Mikkelsen JD, et al. 2001. Hypocretin (orexin) in the rat pineal gland: a central transmitter with effects on noradrenaline-induced release of melatonin. https://onlinelibrary.wiley.com/doi/abs/10.1046/j.0953-816x.2001.01655.x

22. Arumugham V. 2020. Immunological mechanisms explaining the role of vaccines, IgE, mast cells, histamine, elevating ferritin, IL-6, D-dimer, VEGF levels in COVID-19 and dengue, potential treatments such as mast cell stabilizers, antihistamines: Predictions and confirmations.

23. https://www.gov.uk/government/publications/pandemic-flu-vaccine-and-narcolepsy/pandemic-flu-vaccine-and-narcolepsy

24. Anderson G, et al. 2019. Multiple Sclerosis: Melatonin, Orexin, and Ceramide Interact with Platelet Activation Coagulation Factors and Gut-Microbiome-Derived Butyrate in the Circadian Dysregulation of Mitochondria in Glia and Immune Cells. https://www.mdpi.com/1422-0067/20/21/5500