Pfizer used Synthetic Life derived from US Bioweapons research for its mRNA trials

The US Bioweapons effort is known to have introduced the Furin Cleavage site into Coronavirus in 2005. Has anyone found an earlier date for this weaponization?

If you want to turn Coronavirus into a more lethal weapon, you need to make sure its entry into Human cells is enhanced.

The Covid19 virus Spike protein comes as a trimer of intertwined proteins that lock onto membrane bound ACE2 enzyme that is expressed in many cell types throughout the body.¹

Furin is a protease enzyme we have performing many useful functions in our bodies.²

As shown in this figure³ review by German scientists from early 2019, a number of pathogenic viruses exploit our Furin to assist with cell entry, including Mumps, Measles, Avian Influenza, Ebola, Dengue Fever, Hepatitis, Herpes, HIV, and HPV. This has led research into drugs that might inhibit Furin as therapies against the pathogens.⁴

2000 Spain with US help weaponized Coronavirus

Before the introduction of Furin, researchers in Spain set out to “rescue” and weaponize Coronavirus using E coli bacteria strain DH10B.⁵ They took Transmissible GastroEnteritiscoronaVirus (TGEV) PUR46-MAD virus (abbreviated PUR-MAD), an attenuated strain of TGEV that infects newborn piglets. They replaced the Spike gene of the PUR-MAD strain with the Spike gene of the TGEV virulent strain PUR46-C11.

Then they assembled a fully functional infectious cDNA clone, leading to a replication competent Virulent virus able to infect both the Enteric and Respiratory tracts, i.e. designed to kill.

The US helped this research along. Epithelial swine testis (ST) cells were provided by L. Saif of Ohio State University, Wooster, Ohio. Plasmid pBeloBAC11 was provided by H. Shizuya and M. Simon at California Institute of Technology, Pasadena.

Escherichia coli DH10Bstrain F2mcrAD(mrr-hsdRMS-mcrBC) Ø80dlacZDM15DlacX74deoRrecA1endA1araD139 (ara,leu) 7697galUgalKl2rpsLnupG was obtained from GIBCO - now owned by Thermo Fisher Scientific.

Proof of their success in weaponization used 3-day-old breast-fed National Institutes of Health miniswine. Mortality was an impressive 100%.

The cytopathic effects produced by the recombinant virus included induction of cell fusion (Syncytia). The research was funded by the Spanish Government, European Union and Fort Dodge Veterinaria Sociedad Aronima, later acquired by Pfizer.