Lecanemab = Leqembi contains massive Endotoxin that accounts for Side Effects

Huge molecules are great hiding places for Endotoxin and supertoxic Lipid A. Alzheimer's patients receive about 700 Endotoxin Units per expensive hit.

Alzheimer's treatment Lecanemab = Leqembi causes more harm than good as recently posted.¹²³

My friend James was optimistic in November 2022 that perhaps this monoclonal antibody would help Alzheimer’s victims. Please see his post⁴ for references and discussion of side effects, all of which I can attribute to Endotoxin.

Lecanemab side effects include Cerebral Edema, involving the breakdown of the tight endothelial junctions of the blood-brain barrier and subsequent accumulation of fluid that can cause Headache, changes in Mental State, Confusion, Vomiting, Nausea, Tremor and Gait Disturbances.

Cerebral Microhaemorrhages are also initiated.⁵

Readers will recall that Alzheimer’s Disease is caused by Endotoxin and its fragment Lipid A that goes into your brain within minutes of injection.⁶

Postmortem Brain tissue from patients with Alzheimer’s Disease found Endotoxin and Gram-negative bacterial DNA segments localized around amyloid plaques and blood vessels. Here is one of many interesting Figures from Zhan and coworkers.⁷

The caption reads:

Figure 4 Association of lipopolysaccharide (LPS = Endotoxin) and Escherichia coli K99 pili protein with amyloid plaques in Alzheimer disease (AD) brains

There were several different patterns of colocalization of LPS and Aβ_1-40/42 in AD brains. There were clusters of predominantly LPS particles that colocalized with Aβ_1-40/42 (A). There were Aβ_1-40/42 deposits that colocalized with LPS and were surrounded by LPS (B, C). Finally, there were confluent Aβ_1-40/42-stained amyloid plaques that had scattered LPS particles within them (D). These LPS results contrasted with E coli K99 pili protein, which often surrounded small Aβ_1-40/42-stained amyloid plaques (E–G). For larger amyloid plaques (diameter >50 μm), E coli K99 was usually absent (H). Bar = 25 μm.

Inside your brain Endotoxin causes deposition of Amyloid Fibrin⁸ and Galectin expression is involved in the damage.⁹

Endotoxin content of Lecanemab is massive

The very large Lecanemab¹⁰ molecule C₆₅₄₄H₁₀₀₈₈N₁₇₄₄O₂₀₃₂S₄₆

somehow gets into the brain and will carry Endotoxin with it.

The treatment mentioned a dose of 10 milligrams (mg)/kilograms (kg), once every two weeks or about 700 mg for an average adult male. I found multiple websites where the Endotoxin cotent was vague and stated < 1 EU/ml by the LAL test but no actual measurements.

So we can guess 700 Endotoxin Units per injection which is over 100 times the amount in a Pfizer jab.¹¹

October 2024 Update

Thanks to Gautam Goswami on X for alerting us to the fact that TGA Australia decided not to register Lecanemab (Alzheimer’s medication) because of the frequent occurrence of amyloid-related imaging abnormalities (ARIA) in patients treated with LEQEMBI.¹²

I would not be jabbed with Endotoxin contaminated monoclonal antibody - would you?

1. EXPERT COMMENT: Lecanemab - worst cost benefit ratio in history?

2. Investigating the wonder biologic Lecanemab for Alzheimer's Disease

3. Investigating the Miracle Biologic Lecanemab for Alzheimer's Disease - Part 5

4. NEJM Study Finds First-Ever Reduction in Rate of Progression of Alzheimer's... Is Lecanemab a Miracle Drug For AD?

5. https://en.wikipedia.org/wiki/Amyloid-related_imaging_abnormalities

6.

7. Xinhua Zhan, MD, Boryana Stamova, PhD, Lee-Way Jin, MD, Charles DeCarli, MD, Brett Phinney, PhD, and Frank R. Sharp. 2016. Gram-negative bacterial molecules associate with Alzheimer disease pathology. https://www.neurology.org/doi/pdf/10.1212/WNL.0000000000003391

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10. https://en.wikipedia.org/wiki/Lecanemab

11.

12. https://www.tga.gov.au/news/news/tgas-decision-not-register-lecanemab-leqembi