Endotoxin exposure in the Womb causes Abnormal Sexual Orientation in Adults

Does AI driven social media trending news including War in Ukraine, Genocide in Gaza, focus on Pop idols & shiny new Weapons Systems divert attention from known Intergenerational Jab Damage?

Warning, some might find this shocking, but it is not designed to upset readers who might be part of the Lesbian, Gay, Bisexual, Transgender, Intersex, Queer/Questioning, Asexual (LGBTIQA+) community.¹

I was prompted to look at the biochemical mechanisms behind what appears to be a surging trend in government sponsored promotion of “inclusion” and “diversity” and I think those are worthy goals but the hundreds of millions of dollars of Australian taxpayer funds spent on that activity makes me suspicious that we are being prepared to be unquestioning of the cause of increasing abnormal sexual development.

My friend Rob knew I would find this expenditure of a Rainbow Speed Hump in Queensland interesting.

It is in front of Sir Samuel Griffith Centre.

Photo credit.²

One can find similar job creation projects in numerous countries with appropriate search terms.

Previously I wrote about Fluoride as a cause of Gender Dysphoria caused by Fluoride.³

Masculinized Female rodents Mounting Behaviour

Here is a scheme outlining experiments designed to alter the adult sexual behaviour of Sprague Dawley Rats. Note the Female Rat mounting another Female Rat.⁴

Here is the caption:

Figure 1. Prenatal allergic and postnatal immune challenge models. Ovalbumin (OVA) sensitized or control females were bred and challenged intranasally with OVA or vehicle on gestational day (GD) 15, and pups assessed neonatally for brain-resident immune cell numbers or grown to adulthood for sociosexual behavior testing and neuroanatomical assessment. Neonatal offspring from naive dams were challenged on the day of birth with an intraperitoneal injection of lipopolysaccharide (LPS, Endotoxin), and the POA assessed on PN4 for spinophilin protein content.

Endotoxin Contamination of Sigma V Ovalbumin

When I read the article by Lenz et al. I decided to check out the Egg White extract Ovalbumin V supplied by Sigma. It is massively contaminated with Endotoxin!

Here is a paper from 2003 highlighting that fact.⁵

Here is a 2014 paper also highlighting that fact.

Note the caption to the supplementary Figure 2 of Sharry et al.⁶

LPS-rich, Sigma grade V, contained 0.004% endotoxin, (400 ng/10 mg OVA), while LPS-free OVA, Hyglos-Endograde, had undetectable levels.

These workers demonstrated that Endotoxin free Ovalbumin produced no difference to Saline.

A more recent paper by Pang and coworkers alerted the world to Endotoxin Contaminated Ovalbumin making numerous studies invalid.⁷

Here is their abstract and the full paper can be viewed free.

Abstract

Ovalbumin (OVA) is a model antigen commonly incorporated in smartly designed nanoparticles for delivery into antigen-presenting cells (APC), aiming to investigate the immune activity and therapeutic efficacy of nanoparticles that contain immunoregulatory compounds. However, the immunoresponse observed in nano-immunotherapy may unexpectedly arise from endotoxin impurity of OVA in the nanoparticles. Literature review shows that most researchers did not notice the importance of endotoxin-free OVA when used in nano-immunotherapy studies.

Concentration at as low as 5 μg/ml OVA from Sigma-Aldrich (contains 0.625 ng/ml endotoxin) was able to activate APC such as dendritic cells and macrophages.

Here, we proposed that the endotoxin impurity in OVA or the finished nanoproducts should be determined by both Limulus Amebocyte Lysate (LAL) and cell-based assay, to ensure the endotoxin-free quality of the nanoparticles.

The endotoxin in OVA can be removed by endotoxin removal column and phase separation methods and endotoxin-free OVA can be purchased.

This perspective alerts the researchers of endotoxin impurity of OVA that may transfer into the finished nanoparticles and introduce an unfavorable immunoregulatory function with false-positive results.

OVA with minimal endotoxin level should be used in nano-immunotherapy studies to accurately reflect the true effects of nanoparticles on the immune system.

So I conclude that the paper by Lenz et al. actually demonstrates the effect of prenatal exposure to Endotoxin producing Gender Dysfunction. The authors could have done the experiment but instead wrote:

In this study it was the allergic reaction of the mature dam that impacted the developing fetuses and it is unknown if LPS given during the same period of gestation would have a similar impact.

Brazil leading the understanding

In 2014 Penteado and coworkers looked at the the Transgenerational Effects of Endotoxin injected late in pregnancy.⁸

They found Endotoxin disrupts maternal behavior, reduces nest odor preference in pups, and induces anxiety.

It looks like a few of the works of Thiago B. Kirsten might have to be translated to get the most out of this groups systematic studies, but plenty is available to read in english.

Pfizer product known danger of Masculinization

Australian drug regulators have a specific warning for SAYANA Medroxyprogesterone acetate.⁹

Use in Pregnancy - Category D

SAYANA is contraindicated in women who are pregnant. Studies in animals have shown teratogenicity and fetotoxicity with progestogens, including medroxyprogesterone acetate.

In addition, high doses of progestogens can cause masculinisation of the female fetus in animals and several reports suggest an association between intrauterine exposure to progestational drugs in the first trimester of pregnancy and genital abnormalities in male and female fetuses in humans. If SAYANA is used during pregnancy, or if the patient becomes pregnant while using this drug, the patient should be warned of the potential hazard to the fetus

TGA says Endotoxin is present in SAYANA - how much I wonder?

Menigiomas are caused by Endotoxin in Progesterone.¹⁰

In 2010 it was shown that higher number of abnormal embryos during preimplantation days of pregnancy are linked to Endotoxin induced Hormone changes including Progesterone and 17β-estradiol.¹¹

In 2015 researchers in Mexico examined Human Placentas and found that in vitro Progesterone modulates bacterial endotoxin-induced production of IL-1β, TNFα, IL-6, IL-8, IL-10, MIP-1α, and Matrix Metalloprotease 9 (MMP-9) in pre-labor human term placentas.¹²

Feminize your Fish with Endotoxin

The sex ratio of Zebrafish embryos can be altered by exposing the mothers to Endotoxin.¹³

Insect populations affected by Gram-negative Bacteria

Subject for another day. Silkworms and Wasps suffer Femiization from Wolbachia and other Gram-negative Bacteria, so I will have to see what is known about their Endotoxin.¹⁴

Wow! The key to Parthenogenesis - reproduction of infected females without males.

Transgender Women suffer more Endotoxin Harm

In 2022 it was found Transgender Women with HIV suffer stronger reaction to inflammation via the TLR4 pathway.¹⁵

Does this have anything to do with exposures in the womb?

US Government CTD literature

The US Comparative Toxicogeomics Database has a major heading “Disorders of Sex Development”.

That has 13,423 line entries with much duplication lsting chemicals that are associated with this endocrine disruption.

For Endotoxin CTD lists, with associated Genes:

Adrenal Hyperplasia, Congenital CYP17A1

Adrenal hyperplasia, congenital, type 5 CYP17A1

Adrenal Insufficiency, Congenital, With 46,Xy Sex Reversal CYP11A1

Disorder of Sex Development, 46,XY CYP11A1 NR5A1

Gonadal Dysgenesis, 46,XX NR5A1

Gonadal Dysgenesis, 46,XY NR5A1

Lipoid congenital adrenal hyperplasia CYP11A1 STAR

Turner Syndrome CAT NOS2 SOD1 SOD2

For Lipopolysaccharides CTD lists:

46, XX Disorders of Sex Development NR3C1

46,XY SEX REVERSAL 6 MAP3K1

46,XX SEX REVERSAL WITH DYSGENESIS OF KIDNEYS, ADRENALS, AND LUNGS WNT4

Adrenal hyperplasia 2 HSD3B2

Adrenal Hyperplasia, Congenital CYP17A1 HTR4 POR

Adrenal Hyperplasia, Congenital CYP17A1 HSD3B2 POR

Adrenal hyperplasia, congenital, type 5 CYP17A1

Adrenal Insufficiency, Congenital, With 46,Xy Sex Reversal CYP11A1

Androgen-Insensitivity Syndrome AR

Aromatase deficiency CYP19A1

Cortisone reductase deficiency HSD11B1

D-BIFUNCTIONAL PROTEIN DEFICIENCY HSD17B4

Denys-Drash Syndrome WT1

Disorder of Sex Development, 46,XY CYP11A1 LHCGR

Dosage-sensitive sex reversal NR0B1

Frasier Syndrome WT1 PROKR2

Gonadal dysgenesis XX type deafness HSD17B4

Kallmann Syndrome CHD7

Leydig Cell Hypoplasia LHCGR

Lipoid congenital adrenal hyperplasia CYP11A1 STAR

Meacham Winn Culler syndrome WT1

Mullerian Aplasia and Hyperandrogenism WNT4

Ovarian Dysgenesis 2 BMP15

Palmoplantar Hyperkeratosis with Squamous Cell Carcinoma of Skin and Sex Reversal RSPO1

Persistent Mullerian duct syndrome AMH

Pseudovaginal Perineoscrotal Hypospadias SRD5A2

Sexual Infantilism CYP19A1

TESTICULAR ANOMALIES WITH OR WITHOUT CONGENITAL HEART DISEASE GATA4

Turner Syndrome CAT GH1 NOS2 SOD1 SOD2

WAGR Syndrome PAX6 WT1

For Monophosphoryl Lipid A CTD lists:

Turner Syndrome CAT

Population Control Strategy ?

Many people believe that Bill Gates, WEF, WHO are wanting to reduce Human Population Growth by any means possible, but will the “Selfish Gene” defeat their plans?

I am interested in the fact that many homosexual couples or individuals feel the need to raise a family by artificial insemination (e.g. Mary Lea Trump, Senator Penny Wong), paying for Surrogate baby production, or Adoption.

Please provide additional relevant references you might find for Endotoxin producing Gender Dysfunction in later life.

1. https://aifs.gov.au/resources/resource-sheets/lgbtiqa-glossary-common-terms

2. Monica O’Shea. 30 August 2024. Focus LGBTIQA+. Next Census to Include Gender Identity Question After Week of Pressure. The Epoch Times. https://www.theepochtimes.com/focus/lgbtiqa

3.

4. Kathryn M. Lenz, Lindsay A. Pickett, Christopher L. Wright, Anabel Galan and Margaret M. McCarthy. 2019. Prenatal Allergen Exposure Perturbs Sexual Differentiation and Programs Lifelong Changes in Adult Social and Sexual Behavior. https://www.nature.com/articles/s41598-019-41258-2

5. Junji Watanabe, Yasunari Miyazaki, Guy A. Zimmerman, Kurt H. Albertin, Thomas M. McIntyre. 2003. Endotoxin contamination of ovalbumin suppresses murine immunologic responses and development of airway hyper-reactivity. https://www.jbc.org/article/S0021-9258(20)82777-X/fulltext

6. John Mac Sharry, Karim H. Shalaby, Cinzia Marchica, Soroor Farahnak, Tien Chieh-Li, Susan Lapthorne, Salman T. Qureshi, Fergus Shanahan, and James G. Martin. 2014. Concomitant Exposure to Ovalbumin and Endotoxin Augments Airway Inflammation but Not Airway Hyperresponsiveness in a Murine Model of Asthma. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098648

7. Guibin Pang, Yun Liu, Yangyun Wang, Yong Wang, Fujun Wang, Jian Zhao, Leshuai W Zhang. 2022. Endotoxin contamination in ovalbumin as viewed from a nano-immunotherapy perspective. https://wires.onlinelibrary.wiley.com/doi/epdf/10.1002/wnan.1747

8. Sandra H.W. Penteado, Elizabeth Teodorov, Thiago B. Kirsten, Bianca P. Eluf, Thiago M.Reis-Silva, Michelli K.Acenjo, Rafaelde Melo, Ivana B. Suffredini, Maria M.Bernardi. 2014. Prenatal lipopolysaccharide disrupts maternal behavior, reduces nest odor preference in pups, and induces anxiety: Studies of F1 and F2 generations. European Journal of Pharmacology. https://www.sciencedirect.com/science/article/abs/pii/S0014299914004403

9. Therapeutic Goods Administration. 2011. Australian Public Assessment Report for Medroxyprogesterone acetate.

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12.

13. J. Moraleda-Prados, M. Caballero-Huertas, A. Valdivieso, S. Joly, J. Ji, N. Roher, L. Ribas. 2021. Epigenetic differences in the innate response after immune stimulation during zebrafish sex differentiation. https://www.sciencedirect.com/science/article/abs/pii/S0145305X20304031

14. https://en.wikipedia.org/wiki/Wolbachia

15. Aaren Kettelhut, Emily Bowman, Janelle Gabriel, Brittany Hand, Namal P M Liyanage, Manjusha Kulkarni, Frances Avila-Soto, Jordan E Lake, Nicholas T Funderburg. 2022. Estrogen May Enhance Toll-Like Receptor 4-Induced Inflammatory Pathways in People With HIV: Implications for Transgender Women on Hormone Therapy. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.879600/full