Heart Fibrosis caused by Endotoxin
Endotoxin Induced Myocarditis leaves scars due to Fibrosis which contribute to increased risk of Death.
There is no doubt that Endotoxin in Covid19 jabs causes Myocarditis.1
With the surging Excess Deaths after the mass jabbing frenzy, we can expect a significant number of people are dying with permanent Fibrosis effects on their Heart.2
Cardiac fibrosis is a reparative process after Myocardial Infarction, which leads to cardiac remodeling and finally Heart Failure. It has been found that Endotoxin Heart Fibrosis3 damage involves the Inflammasome and activation of Caspase-1.4
Here I look at Fibrosis of the Heart caused by Endotoxin.5
Of course only people from wealthy nations will have access to the advanced imaging technology required to detect scars in their heart, which itself carries risks of further harm or death.6
To June 2022, Pfizer reported cases:
Myocardial fibrosis 65; Pericardial fibrosis 37; Endocardial Fibrosis 2
Pfizer also reported Fibrosis in other or unspecified organs, including:
Pulmonary fibrosis 81; Fibrosis 28; Idiopathic pulmonary fibrosis 23; Hepatic fibrosis 8; Pleural fibrosis 3; Kidney fibrosis 3; Breast fibrosis 2; Lymph node fibrosis 2; Macular fibrosis; Retinal fibrosis 1; Myelofibrosis 6; Primary myelofibrosis 1; Muscle fibrosis 2; Bladder fibrosis 1; Combined pulmonary fibrosis and emphysema 1; Cystic fibrosis 1; Gastric fibrosis 1; Intestinal fibrosis 1; Retroperitoneal fibrosis 2; Vaccination site fibrosis 3; Administration site fibrosis 1; Skin fibrosis 1; Arthrofibrosis 1;
Also of probable relevance, reports of scars:
Scar 243; Bacille Calmette-Guerin scar reactivation 131; Scar pain 81; Itching scar 24; Scardiscomfort 16; Keloid scar 10; Hypertrophic scar 3; Glial scar 2; Skin scar contracture 1
Mechanism of Endotoxin Endothelial Fibrosis
In 2017 Italian researchers reviewed the link between Heart and Kidney damage caused by Endotoxin, including consideration of microRNAs generated in the Cytokine Storm via TLR4.7
Recent data suggest that heart and kidney dysfunctions are associated with the damaging activity of circulating pro-inflammatory and pro-apoptotic mediators, which trigger cellular apoptosis, autophagy, cell cycle arrest and miRNA activation.
Cystic Fibrosis caused by Endotoxin and Cardiac diseases are similarly linked.8
In 2014 researchers in Chile reported that the Ca2+-permeable channel TRPM7 is a crucial protein in the development of Endotoxin-induced Endothelial Fibrosis.9
In my earlier article on Myocarditis caused by the Covid19 jabs, I made reference to recent studies of Cardiac Fibrosis. In particular the paper by Barmada and coworkers10 who found No evidence of cardiac-targeted autoantibodies. They did find elevations in circulating interleukins (IL-1β, IL-1RA, and IL-15), chemokines (CCL4, CXCL1, and CXCL10), and matrix metalloproteases (MMP1, MMP8, MMP9, and TIMP1), all consistent with Endotoxin epigenetics.
Earlier Zhang and coworkers11 performed detailed studies of the catalytic Heart cell Death progression, whereby the initial generation of myocardial cells triggers the death of surroundng cells.
microRNAs in Fibrosis
In 2012 Vettori and coworkers reviewed the role of microRNAs in Fibrosis.12 I will expand this section later.
IgG4 caused by Endotoxin link to Fibrosis
Thanks to one of my readers for reminding me that I briefly covered Endotoxin induced IgG4 disease which can involve Fibrosis in multiple organs.1314
Pfizer Process 2 Endotoxin Myocarditis Death Toll - Dr Aseem Malhotra knows all about it
Jab pushers are outraged at the overwhelming success of the Australian lecture tour by British Cardiologist Dr Aseem Malhotra. So let’s look at Jab Deaths caused by the Heart condition known as Myocarditis. 139 Medically Confirmed Myocarditis Deaths
Sanchez Tijmes F, et al. 2021. Cardiac MRI Assessment of Nonischemic Myocardial Inflammation: State of the Art Review and Update on Myocarditis Associated with COVID-19 Vaccination. https://pubs.rsna.org/doi/full/10.1148/ryct.210252
Lew WYW. 2013. Recurrent Exposure to Subclinical Lipopolysaccharide Increases Mortality and Induces Cardiac Fibrosis in Mice. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061057
Chen J, et al. 2020. Nur77 deficiency exacerbates cardiac fibrosis after myocardial infarction by promoting endothelial-to-mesenchymal transition. https://onlinelibrary.wiley.com/doi/10.1002/jcp.29877
Heart Strings, Ligaments and Tendons damaged by mRNA Jabs linked to Endotoxin
Merck Moderna RSV mRNA Jab trial in Australia 2018 Thanks to Paula Jardine of Trial Site News who alerted me to a small-scale Moderna Respiratory Syncytial Virus (RSV) mRNA Jab study done in Australia in 2018 and published in 2021. The study was funded by
Franckenberg S, et al. 2018. Fatal anaphylactic reaction to intravenous gadobutrol, a gadolinium-based MRI contrast agent. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851274/
Virzì GM, et al. 2018. Endotoxin Effects on Cardiac and Renal Functions and Cardiorenal Syndromes. https://karger.com/bpu/article/44/4/314/326886/Endotoxin-Effects-on-Cardiac-and-Renal-Functions
Eduardo López-Collazo and Carlos del Fresno. 2013. Pathophysiology of endotoxin tolerance: mechanisms and clinical consequences. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059412/
Echeverria C, et al. 2014. the Ca2+-permeable channel TRPM7 is a crucial protein in the development of endotoxin-induced endothelial fibrosis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978016/
Barmada A, et al. 2023. Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis
Zhang W, et al. 2015. Necrotic Myocardial Cells Release Damage‐Associated Molecular Patterns That Provoke Fibroblast Activation In Vitro and Trigger Myocardial Inflammation and Fibrosis In Vivo. https://www.ahajournals.org/doi/full/10.1161/JAHA.115.001993
Vettori S, et al. 2012. Role of MicroRNAs in Fibrosis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396185/
IgG4 affected by Endotoxin in mRNA Jabs
There has been lots of discussion about IgG4 here on Substack and elsewhere recently, increasing with each mRNA Covid19 Jab. The observation that IgG4 increases with age has been attributed to chronic exposure to allergens.Geoff Pain PhD is a reader-supported publication. Please consider becoming a paid subscriber to support my expenses.
Moutsopoulos HM, et al. 2023. https://www.uptodate.com/contents/pathogenesis-and-clinical-manifestations-of-igg4-related-disease
I thought the process 2 only used a couple of hundred people in the recorded data. Did the process 1 version also have endotoxin contamination Geoff or am I mistaken?