IgG4 affected by Endotoxin in mRNA Jabs

Current interest in increased immunoglobulin IgG4 after repeated Covid19 MRNA jabs, and the diseases and Deaths that will cause, prompted me to join a few dots.

There has been lots of discussion about IgG4 here on Substack and elsewhere recently, increasing with each mRNA Covid19 Jab.¹²³⁴

The observation that IgG4 increases with age has been attributed to chronic exposure to allergens.⁵

Let’s start by looking at IgG4-related disease (IgG4-RD), formerly known as IgG4-related systemic disease. It is a chronic inflammatory condition characterized by tissue infiltration with Lymphocytes and IgG4-secreting plasma cells, various degrees of Fibrosis resulting in Tissue Scarring.⁶

IgG4 Diseases include Lymphadenopathy⁷, Atopic Dermatitis, Autoimmune Pancreatitis, Bronchial Asthma, Riedel thyroiditis, Interstitial Pneumonitis, Interstitial Nephritis, Prostatitis, Retroperitoneal Fibrosis, Inflammatory Aortic Aneurysm and many Clotting diseases or other Blood disorders.

Repeated Jabbing increases IgG4

A famous paper by Irrgang and coworkers alerted the jabbing world to this dangerous effect of reduced immunity to Covid19 infection.⁸ The evidence is more clear now that the more doses people receive, the more likely they are to die of the virus infection.

Endotoxin repeated exposure increases IgG4

Gram-negative Endotoxin is clearly implicated in IgG4 disease.⁹¹⁰¹¹

Septic Pancreatitis and Hypergammaglobulinaemia with disruption of IgG4 have been linked to E coli Endotoxin.¹²

Galectin involved in IgG4 Autoimmunity

John Paul has written here about Galectin¹³¹⁴ as an antigen associated with IgG4 Disease that drives expansion of circulating plasmablasts and CD4⁺ cytotoxic T cells in patients.¹⁵ Galectin is a marker of severe Covid19.¹⁶ Jessica Rose mentioned Galectin in her Stockholm lecture.

Galectin enhances the Endotoxin inflammatory response. Galectin was shown to allow low Endotoxin (LPS) concentrations (1 µg/mL without serum, 1 ng/mL with serum) to upregulate CD11b expression and Reactive Oxygen Species (ROS) generation on Human Neutrophils in vitro and drastically enhanced the binding efficiency of LPS to the neutrophil surface.¹⁷

Another paper reports the disaggregation of Endotoxin micelles with details at molecular level.¹⁸ See also my earlier article.¹⁹

Repeated mRNA Covid 19 jabs reduce Immunity

A recent paper by Uversky and coworkers²⁰ discusses how the alteration of the immune system, shifting to IgG4 reduces immunity, as seen in their Figure 4.

Repeated vaccination induces high IgG4 levels (depicted in red). This antibody inhibits the attachment of the Fc region from the IgG3 antibody to its receptor located on cytotoxic T cells, thus blocking its activation, and consequently, the infected cell is not destroyed.

WHO admits Defeat

WHO admitted defeat by the mutating Covid19 virus. They don't want any Covid19 jabs that contain synthetic antigens to the original WUHAN lab leak. WHO is officially worried about IgG4 class switching weakening the Human Immune system.²¹

Repeated mRNA jabbing increases Cancer risk

In an earlier article I reported that Endotoxin in mRNA jabs will increase Cancers.²² During his lecture and in private discussion afterwards at the AMPS event held in Melbourne on 31 May 2023, Emeritus Professor Robert Clancy mentioned the dangers of IgG4 Disease and Melanoma and other cancer susceptibility.

In 2020, Jiang Gu and coworkers²³²⁴ found that IgG4 suppresses our capacity to fight off Cancers and actually accelerated Breast and Colorectal cancers and carcinogen-induced Skin Papilloma.

illustration of proposed mechanism of cancer-initiated B lymphocyte-derived IgG4-mediated immune evasion. Chronic stimulation by cancer antigens induces class switch of B lymphocytes to produce IgG4. Such increased IgG4 can react to cancer-bound IgG with its Fc-Fc binding property and also to Fc receptors of immune effector cells. With its unique structural and biological property, increased IgG4 in cancer microenvironment mediates an effective immune escape for cancer. ADCC, antibody-dependent cell-mediated cytotoxicity; ADCP, antibody-dependent cellular phagocytosis; CDC, complement-dependent cytotoxicity; NK, natural killer cells.

See a recent update by Igor Chudov on Turbocancer linked to IgG4.²⁵

Hungarian Study

Thanks to Australian author Aussie17²⁶ for pointing me toward the new IgG class switching study²⁷ from Hungary of 47 people who had various vaccination history with homologous or heterologous boosters. The study showed that:

In addition to IgG1 and IgG3 subclasses presented in all groups, a switch towards distal IgG subclasses (spike-specific IgG4 and IgG2) appeared almost exclusively in individuals who received only mRNA vaccines or were infected after mRNA vaccinations.

People who had been jabbed with Adenovirus vectors had negligible IgG4, which requires further explanation. See a recent update by our friend Doorless Carp.²⁸

Conclusion

The shift to increased IgG4 observed after multiple mRNA Covid19 does not have to involve the Synthetic Spike Protein, as the Endotoxin load is sufficient to induce this dangerous effect. I expect this will create some discussion and will add further references soon.

1. "IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein"

2. The immunological mechanism of action for lost immunity, a shift to tolerance (and autoimmunity?) from the shots

3. https://www.uncoverdc.com/2023/05/30/igg4-increases-with-repeated-mrna-vaccines-linked-to-disease/

4. Long before EUA, FDA and vaccine makers were warned about induction of inappropriate IgE and IgG4 antibodies by COVID vaccines. They ignored it. Prediction comes true, with devastating consequences.

5. Aalberse RC, et al. 1983. Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response. https://journals.aai.org/jimmunol/article-abstract/130/2/722/15158/Serologic-aspects-of-IgG4-antibodies-I-Prolonged

6. https://en.wikipedia.org/wiki/IgG4-related_disease

7.

8. Irrgang P, et al. Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination. https://www.science.org/doi/10.1126/sciimmunol.ade2798

9. Smoldovskaya O, et al. 2018. Allergen-specific IgE and IgG4 patterns among patients with different allergic diseases. https://waojournal.biomedcentral.com/articles/10.1186/s40413-018-0220-5

10. Arduino MJ, et al. 1989. Growth and endotoxin production of Yersinia enterocolitica and Enterobacter agglomerans in packed erythrocytes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC267599/

11. Rastawicki W and Jakubczak A. 2007. Serum immunoglobulin IgG subclass distribution of antibody responses to Yop proteins and lipopolysaccharide of Yersinia enterocolitica in patients with yersiniosis. https://www.researchgate.net/publication/5598736_Serum_immunoglobulin_IgG_subclass_distribution_of_antibody_responses_to_Yop_proteins_and_lipopolysaccharide_of_Yersinia_enterocolitica_in_patients_with_yersiniosis

12. Tuuminen T, et al. 2016. Relapsing sepsis episodes of Escherichia coli with CTX-M ESBL or derepressed ampC genes in a patient with chronic autoimmune pancreatitis complicated by IgG4 hypergammaglobulinaemia. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708074/

13. Chimeric nature of Galectin-3 and SARS-CoV-2

14. Galectin-3 causes CD8 dysfunction in severe Covid-19 cases

15. Perugino CA, et al. 2018, Identification of galectin-3 as an autoantigen in patients with IgG₄-related disease. https://www.jacionline.org/article/S0091-6749(18)30768-1/fulltext

16. Cervantes‑Alvarez E, et al. 2022. Galectin‑3 as a potential prognostic biomarker of severe COVID‑19 in SARS‑CoV‑2 infected patients. https://www.nature.com/articles/s41598-022-05968-4

17. Lopes Fermino M, et al. LPS-Induced Galectin-3 Oligomerization Results in Enhancement of Neutrophil Activation. 2011. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026004

18. Samsudin F, et al. 2022. SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade. https://academic.oup.com/jmcb/article/14/9/mjac058/6761401

19.

20. Uversky VN, et al. 2023. IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein. https://www.mdpi.com/2076-393X/11/5/991

21. https://www.who.int/news/item/18-05-2023-statement-on-the-antigen-composition-of-covid-19-vaccines

22.

23. Wang H, et al. 2020. An immune evasion mechanism with IgG4 playing an essential role in cancer and implication for immunotherapy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443307/

24. Wang H, et al. 2020. An immune evasion mechanism with IgG4 playing an essential role in cancer and implication for immunotherapy. https://jitc.bmj.com/content/8/2/e000661.long

25. 'Hyperprogressive' Cancers Due to COVID Vaccine-Caused IgG4 Antibodies

26. A possible explanation of Sweden's low excess mortality!! Mystery solved??

27. Kiszel P, et al. 2023. Class switch towards spike protein-specific IgG4 antibodies after SARS-CoV-2 mRNA vaccination depends on prior infection history. https://www.nature.com/articles/s41598-023-40103-x

28. SARS-CoV-2 spike protein, homologous Galectin-3 and class switching to IgG4