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IgG4 affected by Endotoxin in mRNA Jabs

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IgG4 affected by Endotoxin in mRNA Jabs

Current interest in increased immunoglobulin IgG4 after repeated Covid19 MRNA jabs, and the diseases and Deaths that will cause, prompted me to join a few dots.

GeoffPainPhD
May 31, 2023
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IgG4 affected by Endotoxin in mRNA Jabs

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There has been lots of discussion about IgG4 here on Substack and elsewhere recently, increasing with each mRNA Covid19 Jab.

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The observation that IgG4 increases with age has been attributed to chronic exposure to allergens.

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Let’s start by looking at IgG4-related disease (IgG4-RD), formerly known as IgG4-related systemic disease. It is a chronic inflammatory condition characterized by tissue infiltration with Lymphocytes and IgG4-secreting plasma cells, various degrees of Fibrosis resulting in Tissue Scarring.

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IgG4 Diseases include Lymphadenopathy

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, Atopic Dermatitis, Autoimmune Pancreatitis, Bronchial Asthma, Riedel thyroiditis, Interstitial Pneumonitis, Interstitial Nephritis, Prostatitis, Retroperitoneal Fibrosis, Inflammatory Aortic Aneurysm and many Clotting diseases or other Blood disorders.

Repeated Jabbing increases IgG4

A famous paper by Irrgang and coworkers alerted the jabbing world to this dangerous effect of reduced immunity to Covid19 infection.

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The evidence is more clear now that the more doses people receive, the more likely they are to die of the virus infection.

Endotoxin repeated exposure increases IgG4

Gram-negative Endotoxin is clearly implicated in IgG4 disease.

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Septic Pancreatitis and Hypergammaglobulinaemia with disruption of IgG4 have been linked to E coli Endotoxin.

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Galectin involved in IgG4 Autoimmunity

John Paul has written here about Galectin

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as an antigen associated with IgG4 Disease that drives expansion of circulating plasmablasts and CD4+ cytotoxic T cells in patients.
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Galectin is a marker of severe Covid19.
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Jessica Rose mentioned Galectin in her Stockholm lecture.

Galectin enhances the Endotoxin inflammatory response. Galectin was shown to allow low Endotoxin (LPS) concentrations (1 µg/mL without serum, 1 ng/mL with serum) to upregulate CD11b expression and Reactive Oxygen Species (ROS) generation on Human Neutrophils in vitro and drastically enhanced the binding efficiency of LPS to the neutrophil surface.

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Another paper reports the disaggregation of Endotoxin micelles with details at molecular level.

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See also my earlier article.
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Repeated mRNA Covid 19 jabs reduce Immunity

A recent paper by Uversky and coworkers

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discusses how the alteration of the immune system, shifting to IgG4 reduces immunity, as seen in their Figure 4.

Repeated vaccination induces high IgG4 levels (depicted in red). This antibody inhibits the attachment of the Fc region from the IgG3 antibody to its receptor located on cytotoxic T cells, thus blocking its activation, and consequently, the infected cell is not destroyed.

WHO admits Defeat

WHO admitted defeat by the mutating Covid19 virus. They don't want any Covid19 jabs that contain synthetic antigens to the original WUHAN lab leak. WHO is officially worried about IgG4 class switching weakening the Human Immune system.

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Repeated mRNA jabbing increases Cancer risk

In an earlier article I reported that Endotoxin in mRNA jabs will increase Cancers.

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During his lecture and in private discussion afterwards at the AMPS event held in Melbourne on 31 May 2023, Emeritus Professor Robert Clancy mentioned the dangers of IgG4 Disease and Melanoma and other cancer susceptibility.

In 2020, Jiang Gu and coworkers

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found that IgG4 suppresses our capacity to fight off Cancers and actually accelerated Breast and Colorectal cancers and carcinogen-induced Skin Papilloma.

Hungarian Study

Thanks to Australian author Aussie17

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for pointing me toward the new IgG class switching study
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from Hungary of 47 people who had various vaccination history with homologous or heterologous boosters. The study showed that:

In addition to IgG1 and IgG3 subclasses presented in all groups, a switch towards distal IgG subclasses (spike-specific IgG4 and IgG2) appeared almost exclusively in individuals who received only mRNA vaccines or were infected after mRNA vaccinations.

People who had been jabbed with Adenovirus vectors had negligible IgG4, which requires further explanation. See a recent update by our friend Doorless Carp.

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Conclusion

The shift to increased IgG4 observed after multiple mRNA Covid19 does not have to involve the Synthetic Spike Protein, as the Endotoxin load is sufficient to induce this dangerous effect. I expect this will create some discussion and will add further references soon.

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Unacceptable Jessica
"IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein"
Please refer to the newly published paper entitled: “IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein” published in Vaccines on May 17, 2023. The paper has remarkable findings and concludes that…
Read more
4 months ago · 417 likes · 145 comments · Jessica Rose
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Unacceptable Jessica
The immunological mechanism of action for lost immunity, a shift to tolerance (and autoimmunity?) from the shots
If you want some proof to show pro-COVID shot nay-sayers that these shots are detrimental to normal functioning immune responses, read them this. Before I get into this paper that should stop the presses and provide a one-way ticket for a lot of people to prison for the rest of their lives (as a best punishment), I refer to an earlier article that I wro…
Read more
9 months ago · 522 likes · 22 comments · Jessica Rose
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https://www.uncoverdc.com/2023/05/30/igg4-increases-with-repeated-mrna-vaccines-linked-to-disease/

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Vinu’s Newsletter
Long before EUA, FDA and vaccine makers were warned about induction of inappropriate IgE and IgG4 antibodies by COVID vaccines. They ignored it. Prediction comes true, with devastating consequences.
When a food protein is injected (contaminated vaccine) the body creates IgE (immunoglobulin E) antibodies that recognize the food protein. With more injections or eating that protein, the body starts making IgG4 (immunoglobulin G, subclass 4) antibodies against that protein…
Read more
9 months ago · 100 likes · 33 comments · Vinu Arumugham #Kennedy24
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Aalberse RC, et al. 1983. Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response. https://journals.aai.org/jimmunol/article-abstract/130/2/722/15158/Serologic-aspects-of-IgG4-antibodies-I-Prolonged

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https://en.wikipedia.org/wiki/IgG4-related_disease

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Lymphadenopathy Danger from Endotoxin in Pfizer Jabs

GeoffPainPhD
·
Jun 3
Lymphadenopathy Danger from Endotoxin in Pfizer Jabs

BioNTech/Pfizer and complicit marketers of their Covid19 jab, including government departments around the globe, lied to the public when the said that the Lipid NanoParticles and the mRNA floating inside or outside them, would simply enter muscle cells in the arm, take them over to force them to become factories for Synthetic Spike generation and result…

Read full story
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Irrgang P, et al. Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination. https://www.science.org/doi/10.1126/sciimmunol.ade2798

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Smoldovskaya O, et al. 2018. Allergen-specific IgE and IgG4 patterns among patients with different allergic diseases. https://waojournal.biomedcentral.com/articles/10.1186/s40413-018-0220-5

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Arduino MJ, et al. 1989. Growth and endotoxin production of Yersinia enterocolitica and Enterobacter agglomerans in packed erythrocytes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC267599/

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Rastawicki W and Jakubczak A. 2007. Serum immunoglobulin IgG subclass distribution of antibody responses to Yop proteins and lipopolysaccharide of Yersinia enterocolitica in patients with yersiniosis. https://www.researchgate.net/publication/5598736_Serum_immunoglobulin_IgG_subclass_distribution_of_antibody_responses_to_Yop_proteins_and_lipopolysaccharide_of_Yersinia_enterocolitica_in_patients_with_yersiniosis

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Tuuminen T, et al. 2016. Relapsing sepsis episodes of Escherichia coli with CTX-M ESBL or derepressed ampC genes in a patient with chronic autoimmune pancreatitis complicated by IgG4 hypergammaglobulinaemia. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708074/

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Things Hidden in Complexity
Chimeric nature of Galectin-3 and SARS-CoV-2
In memory of a dear friend of mine. Both of the following Substacks are borderline must-read to understand how impactful what we are about to discuss here. Spike Protein as an endotoxin delivery system, and The Shift in mRNA Immunity. First, we need to clarify what are Galectins, before going any further…
Read more
10 months ago · 64 likes · 31 comments · John Paul
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Things Hidden in Complexity
Galectin-3 causes CD8 dysfunction in severe Covid-19 cases
Both of the following papers are directly correlated with the following substack, while I often don’t repeat myself and left for the readers to “dig”, this is one of the very few substacks I break this unofficial rule, it is one of the most important dynamics of the virus and the Spike Protein, therefore the overall pathophysiology, and it will influen…
Read more
5 months ago · 40 likes · 6 comments · John Paul
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Perugino CA, et al. 2018, Identification of galectin-3 as an autoantigen in patients with IgG4-related disease. https://www.jacionline.org/article/S0091-6749(18)30768-1/fulltext

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Cervantes‑Alvarez E, et al. 2022. Galectin‑3 as a potential prognostic biomarker of severe COVID‑19 in SARS‑CoV‑2 infected patients. https://www.nature.com/articles/s41598-022-05968-4

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Lopes Fermino M, et al. LPS-Induced Galectin-3 Oligomerization Results in Enhancement of Neutrophil Activation. 2011. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026004

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Samsudin F, et al. 2022. SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade. https://academic.oup.com/jmcb/article/14/9/mjac058/6761401

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GMO Spike Protein carries E coli Endotoxin and enhances Inflammatory Damage to Jabbees

GeoffPainPhD
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Feb 14
GMO Spike Protein carries E coli Endotoxin and enhances Inflammatory Damage to Jabbees

A very useful paper by Petruk et al. published in December 2020 assists greatly in understanding the structures and toxicity of E. coli Endotoxins, also known as LPS (LipoPolySaccharides) from the surface of the bacteria cells and the “smaller” fragments, known as “Lipid A” that break off when the cells are disrupted.

Read full story
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Uversky VN, et al. 2023. IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein. https://www.mdpi.com/2076-393X/11/5/991

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https://www.who.int/news/item/18-05-2023-statement-on-the-antigen-composition-of-covid-19-vaccines

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Pfizer Jab Endotoxins will cause more Cancer

GeoffPainPhD
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Mar 2
Pfizer Jab Endotoxins will cause more Cancer

Pfizer reports Thousands of Cancers after their Jabs In April 2022 Pfizer reported Thousands of Cancer cases and deliberately spread the clear Warning Signal by dispersing them under 496 different types under the general heading “Neoplasms benign, malignant and unspecified (incl cysts and polyps)”.

Read full story
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Wang H, et al. 2020. An immune evasion mechanism with IgG4 playing an essential role in cancer and implication for immunotherapy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443307/

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PharmaFiles by Aussie17
A possible explanation of Sweden's low excess mortality!! Mystery solved??
One of the greatest mysteries I have encountered is the remarkably low excess mortality in Sweden, despite the extensive administration of mRNA vaccines. Recall that we have recently seen several studies indicating that IgG4 plays a negative role, contributing to…
Read more
a month ago · 14 likes · 4 comments · Aussie17
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Kiszel P, et al. 2023. Class switch towards spike protein-specific IgG4 antibodies after SARS-CoV-2 mRNA vaccination depends on prior infection history. https://www.nature.com/articles/s41598-023-40103-x

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DoorlessCarp’s Scientific Literature Reviews
SARS-CoV-2 spike protein, homologous Galectin-3 and class switching to IgG4
Reading time: about 50 minutes. Also available in other languages: 🇫🇷 https://doorlesscarp953-substack-com.translate.goog/p/sars-cov-2-spike-protein-homologous?_x_tr_sl=en&_x_tr_tl=fr&_x_tr_hl=en-US&_x_tr_pto=wapp 🇪🇸 https://doorlesscarp953-substack-com.translate.goog/p/sars-cov-2-spike-protein-homologous?_x_tr_sl=en&_x_tr_tl=es&_x_tr_hl=en-US&_x_tr_pt…
Read more
22 days ago · 6 likes · DoorlessCarp🐭

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