Heart Strings, Ligaments and Tendons damaged by mRNA Jabs linked to Endotoxin

Have you noticed an increase in people who suffer disabling injury other than Myocarditis and Pericarditis after their mRNA jab?

Merck Moderna RSV mRNA Jab trial in Australia 2018

Thanks to Paula Jardine of Trial Site News¹ who alerted me to a small-scale Moderna Respiratory Syncytial Virus (RSV) mRNA Jab study done in Australia² in 2018 and published in 2021.

The study was funded by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA and authors included employees and shareholders of these companies and of Moderna Inc., Cambridge, MA, USA. Paula Jardine has covered details of the intellectual property deals done in relation to these mRNA jabs.³

Many of the Adverse Reactions involved damage to Ligaments and Tendons that were ignored by the trial organizers who denied they could be related to the test jab.

Participants received mRNA-1777 (V171) or placebo as a single intramuscular dose. For each dose level, three sentinel participants were administered open-label mRNA-1777 (V171). Seventy-two younger adults were randomized and administered 25, 100, or 200 μg mRNA-1777 (V171) or placebo, and 107 older adults were randomized and administered 25, 100, 200 or 300 μg mRNA-1777 (V171) or placebo.

This study suffered loss of subjects and withdrawals, suggesting Adverse Events were far from mild. There was 1 Death in the Placebo group.

Physical examinations were conducted at screening and Days 1 (baseline), 8, 29, 180, and 366. Electrocardiograms were taken at screening and Day 1. Clinical laboratory assessments were taken at screening and Days 1, 2, 8, and 29. Safety was assessed by collecting solicited adverse events (AEs) (local and systemic reactogenicity events) for 7 days post-vaccination, unsolicited AEs for 90 days post-vaccination, and serious AEs, adverse events of special interest (AESI), medically attended AEs, and new onset of chronic medical illness (NOCIs) for 1 year following vaccination.

The intensity of AEs and laboratory abnormalities was categorized by the investigator as mild (Grade 1), moderate (Grade 2), severe (Grade 3), or possibly life-threatening (Grade 4) using the Toxicity Grading Scale for Healthy Adult and Adolescent Volunteers Enrolled in Preventative Vaccine Clinical Trials as a guideline.

Jabbees suffered systemic inflammation:

Dose-dependent increases from baseline in mean bilirubin, C-reactive protein, leukocyte, and neutrophil levels were observed on Day 2 in vaccinated subjects and generally returned to baseline by Day 8.

CD4 T-cells were positive for IFN-γ, IL-2 or TNF-α as measured in intracellular cytokine staining.

Paula Jardine reported:

Moderna reported in its December 2018 prospectus: ‘As of September 19, 2018, we have observed 15 SAEs in nine subjects, all of which were deemed unrelated to study product. These SAEs occurred approximately one to ten months from receipt of study product and included aortic aneurysm repair, paralytic ileus, spinal decompression, death from pre-existing cardiomyopathy, hernia, transient ischemic attack, peripheral vascular disorder, vasovagal syncope, diagnosis of non-small cell lung cancer, anterior cruciate ligament tear, left knee tendon tear, right knee tendon tear, left patella dislocation, right patella dislocation, and bilateral patella tendon repair.’ In addition it stated, ‘Merck has initiated plans for a Phase 2a trial, for which Merck will be the sponsor. In addition, we are working with Merck to identify and advance improvements to the RSV vaccine.

Note the Ligament and Tendon damage.

Pfizer reports to June 2022

In its PSUR3, Pfizer reported the following case numbers

Ligament injury 13; Ligament Rupture 21; Ligament sprain 135; Ligament disorder 12; Ligamentitis 11; Ligament laxity 3; Ligament pain 36; Mucoid degeneration of the anterior cruciate ligament 1; Posterior tibial tendon dysfunction 2; Tendinous contracture 4; Tendon calcification 11; Tendon discomfort 54; Tendon disorder 191; Tendonitis 634; Tendon laxity 2; Tendon pain 389; Tendon rupture 90; Tendon injury 33; Tendon Sheath disorder 17; Tenosynovitis 156; Infective Tenosynovitis 4; Tenosynovitis Stenosans 15; Tenodesis 2; Giant cell tumour of tendon sheath 1; Chordae Tendinae Rupture 4

The last one on the list, Chordae Tendinae (Heart Strings) Rupture is of particular concern, as such cases could prove Fatal or lead to permanent heart dysfunction.⁴⁵

Endotoxin damage to Ligaments and Tendons

In a 2021 review, Tendon damage and repair was related to inflammatory Cytokines from chronic infection.⁶

Stimulation of a type 1 immune response produces cytokines that stimulate innate (IL1β, TNFα, IL6, and IL1) and adaptive (IL12, IFNγ, IL17) immune response. Similarly, release of IL4, IL5, and IL33 induces a type 2 immune response, while IL10 acts primarily to resolve acutely produced type 1 cytokines. Type 1 and type 2 cytokines counter-regulate, to establish the predominant immune signature. Importantly, effective tissue regeneration depends on the balance of inflammatory programs, where overactive type 1 inflammation can result in sudden inflammatory response syndrome (SIRS) or cytokine storm, while excessive type 2 inflammation drives tissue fibrosis.

Readers will recognize these Cytokines as being caused by Endotoxin and recall that dose is unimportant because Interleukin 1 Beta, IL1β, is self-amplifying via positive feedback loop attack on human cells.

Periodontal Ligament destroyed by Endotoxin

Autophagy in dental ligament is induced by Endotoxin.⁷ Inflammatory cytokines are important in the development of Periodontal disease.⁸

Cartilage destruction by Endotoxin

While considering Ligament and Tendon damage reported while exercising, Cartilage damage is known to be caused Endotoxin.⁹

mRNA to repair damaged Tendons?

Experiments have been performed to repair damaged tendons with chemically modified mRNA jabs¹⁰ so don’t worry if one jab causes your problem, another jab will perhaps be sold to repair you!

Large scale study from Korea

Published 22 November 2023, a large study of Covid19 jab harms found massive levels of musculoskeletal damage.¹¹

Results Among the 2,218,715 individuals, 1,882,640 (84.9%) received two doses of the COVID-19 vaccine, and 336,075 (15.1%) did not. At 12 weeks after vaccination, the incidences of plantar fasciitis (0.14-0.17%), rotator cuff syndrome (0.29-0.42%), adhesive capsulitis (0.29-0.47%), HIVD (Herniated Intervertebral Disc 0.18-0.23%), spondylosis (0.14-0.23%), bursitis (0.02-0.03%), Achilles tendinitis (0.0-0.05%), and de-Quervain tenosynovitis (0.04-0.05%) were higher in all three vaccinated groups (mRNA, cDNA, and mixing and matching vaccines) when compared to the unvaccinated group. All COVID-19 vaccines were identified as significant risk factors for each inflammatory musculoskeletal disorder (odds ratio, 1.404-3.730), except for mixing and matching vaccines for de-Quervain tenosynovitis.

The authors make no mention of mechanisms.

Questions arising

How much Endotoxin was in the Merck/Moderna RSV jab?

1. Paula Jardine. 2023. Did Moderna Materially Misrepresent its COVID-19 Vax Research. https://www.trialsitenews.com/a/title-title-title-title-title-title-title-title-title-69394657

2. Antonios O Aliprantis, Christine A Shaw, Paul Griffin, Nicholas Farinola, Radha A Railkar, Xin Cao, Wen Liu, Jeffrey R Sachs, Christine J Swenson, Heather Lee, Kara S Cox, Daniel S Spellman, Colleen J Winstead, Igor Smolenov, Eseng Lai, Tal Zaks, Amy S Espeseth, Lori Panther. 2021. A phase 1, randomized, placebo-controlled study to evaluate the safety and immunogenicity of an mRNA-based RSV prefusion F protein vaccine in healthy younger and older adults. https://www.tandfonline.com/doi/full/10.1080/21645515.2020.1829899

3. Paula Jardine. 2023. The murky past of Moderna, the UK’s £1billion pharma partner. https://www.conservativewoman.co.uk/the-murky-past-of-moderna-the-uks-1billion-pharma-partner/

4. https://en.wikipedia.org/wiki/Chordae_tendineae

5. https://en.wikipedia.org/wiki/Mitral_regurgitation

6. Varun Arvind and Alice H Huang. 2021, Reparative and Maladaptive Inflammation in Tendon Healing. https://www.frontiersin.org/articles/10.3389/fbioe.2021.719047/full

7. Zhuang H, et al. 2016. Autophagy in dental tissues: a double-edged sword. https://www.nature.com/articles/cddis2016103

8. Shindo S, et al. 2014. Genipin inhibits MMP-1 and MMP-3 release from TNF-a-stimulated human periodontal ligament cells. https://www.sciencedirect.com/science/article/abs/pii/S0300908414002946

9. Lorenz W, et al. 2013. Bacterial lipopolysaccharides form procollagen-endotoxin complexes that trigger cartilage inflammation and degeneration: implications for the development of rheumatoid arthritis. https://arthritis-research.biomedcentral.com/articles/10.1186/ar4291

10. Groth K, et al. 2017. Tendon healing induced by chemically modified mRNAs. https://www.ecmjournal.org/papers/vol033/vol033a22.php

11. Young Hwan Park, Min Ho Kim, Myeong Geun Choi and Eun Mi Chun. 2023. Correlation between COVID-19 vaccination and inflammatory musculoskeletal disorders. https://www.medrxiv.org/content/10.1101/2023.11.14.23298544v1