Rhabdomyolysis from Covid19 Jabs

Fatality rate of 6.5%. Severe Muscle wasting might be given a number of names including Cachexia. What could be the cause?

To June 2022, Pfizer reported 294 cases of Rhabdomyolysis among 539,299 Musculoskeletal and connective tissue Adverse Events listed under 353 different such disorders after their Covid19 jabs.

Nineteen of these cases were Fatal from a total of 13,659 Deaths reported to that date.¹

Death from Rhabdomyolysis can involve multiple organs.²

During the Pfizer Process 1 jab trial, one Placebo recipient and no Jab recipients reported Rhabdomyolysis.

Case reports provide useful detail of Pfizer Rhabdomyolosis.³

A 37-year-old man presented to the Emergency Department (ED) with a 3-day history of back pain and a 1-day history of left upper limb swelling with paresthesia and shortness of breath, 12-days after receiving the first dose of Pfizer/BioNTech BNT162b2 mRNA COVID-19 vaccine. He was diagnosed with severe myositis complicated with rhabdomyolysis and non-oliguric acute kidney injury, thrombocytopenia, myocarditis with pulmonary edema, and pulmonary hemorrhage. Screens for potential toxic, infectious, paraneoplastic, and autoimmune disorders were unremarkable. The patient was treated with a 5-day course of intravenous methylprednisolone and intravenous immunoglobulin, with a good response. He was hospitalized for 16 days and discharged home on a tapering dose of oral prednisolone for 6 weeks.

Non-fatal case reports with Pfizer jab.⁴⁵⁶

Fatal Rhabdomyolysis after Moderna Jab

Like Pfizer, Moderna has claimed lives with this Adverse Reaction.⁷⁸

Other Moderna cases have been reported, including identification of genetic risks.⁹¹⁰¹¹

Fatal Rhabdomyolysis after AstraZeneca Jab

A fatal case of Rhabdomyolysis after an AstraZeneca jab¹² was reported in 2021.

On Apr 28, 2021 a 68-year-old man who was previously healthy presented with an extremely severe rhabdomyolysis that occurred nine days following the first dose of SARS-CoV-2 ChAdOx1 nCov-19 vaccination. He had no risk factors, and denied any further assumption of drugs except for fermented red rice, and berberine supplement. The clinical scenario was complicated by a multi organ failure involving bone marrow, liver, lung, and kidney. For the rapid increase of the inflammatory markers, a cytokine storm was suspected and multi-target biologic immunosuppressive therapy was started, consisting of steroids, anakinra, and eculizumab, which was initially successful resulting in close to normal values of creatine phosphokinase after 17 days of treatment.

Unfortunately, 48 days after the vaccination an accelerated phase of deterioration, characterized by severe multi-lineage cytopenia, untreatable hypotensive shock, hypoglycemia, and dramatic increase of procalcitonin (PCT), led to patient death.

The authors considered mechanisms including:

tissue hypoxia, direct bacterial invasion of muscle, low oxidative and glycolytic enzyme activity, activation of lysosomal enzymes and mechanisms implicating endotoxins or autoimmunity due molecular mimicry.

A non-fatal AstraZeneca case identified Carnitine palmitoyltransferase II as a risk factor.¹³

Janssen Rhabdomyolysis cases

A survivor case report.¹⁴

Acute Kidney Injury induced by Rhabdomyolysis

Rhabdomyolysis is a condition that results in the release of Creatine Kinase and Myoglobin from the breakdown of myocytes. Myoglobin has been known to cause renal failure.

A 68-year-old man developed an acute Rhabdomyolysis triggered by influenza vaccination while taking statins for a long period.¹⁵

The role of microRNA miR-22 and Hypoxia-Inducible Factors were studied by Mathia and coworkers.¹⁶ miR-22 is known to be upregulated by Endotoxin via TLR4.¹⁷

Renal HIF-1-endothelin-1 is known to be upregulated by Endotoxin.¹⁸

Rhabdovirus Contamination of NovaVax

Japanese authorities detected Rhabdovirus contamination of NovaVax.¹⁹

Endotoxin the cause of Cachexia

Given that Rhabdomyolysis has been reported for all the major brands of Covid19 jabs it seems likely there will be a common factor.

Gram-negative Bacteria are a known cause of Rhabdomyolysis assocoated with sepsis, often fatal.²⁰

In an earlier article I reported that Peter Hotez was able to induce Muscle Wasting, more commonly known then as Cachexia, using Endotoxin.²¹

Studies of Cancer Cachexia identified the Endotoxin induced inflammatory Cytokines TNF-α, IL-1 and IL-6 as key drivers.²²

Cramer and coworkers²³ provided further detail and were able to prevent Cachexia by inhibition of Eukaryotic Initiation Factor 4A (eIF4A), by modulating the translation of the inducible Nitric Oxide Synthase (iNOS) mRNA. They further demonstrated that:

concurrent signaling of Interferon γ (IFNγ) and Tumor Necrosis Factor α (TNFα) (IT) can synergistically elicit muscle wasting by stimulating the activity of transcription factors including STAT3 and the heterodimeric NF-κB9–12. NF-κB signaling in skeletal muscle upregulates the muscle-specific E3 ligase MURF-1 and induces a loss of proteins integral for muscle fiber formation and maintenance, such as MyoD and Myogenin.

So it was entirely predictable that Covid19 jabs would cause hundreds of different types of Musculoskeletal and Connective tissue Adverse Events.

Acknowledgements

Thanks to the Thorp family, whose review pointed me toward a number of case reports.²⁴ After circulating this article I discovered that Dr Robert W. Chandler published a review on in April 2023²⁵ and there was an earlier review by Kimura and colleagues but neither traced the cause.²⁶

A friend in Canada who is expert in Gq/11 pathways provides a very interesting collection of references showing similarities to Fluoride induced Rhabdomyolysis.²⁷

Found a Fatal case caused by Rabies involving Rhabdomyolysis.²⁸

1. Pfizer. Summary Tabulation of Fatal Cases and Adverse Events by System Organ Class (SOC) and Preferred Terms (PT) by Age Group BNT162B2; BNT162B2 OMI; BNT162B2S01 - ALL Reporting Period: 19-DEC-2021 Through 18-JUN-2022 Total Number of Cases: 13659 (100%) (ALL) / 13659 (OVERALL) Total Number of Adverse Events (PT): 52858 (ALL)

2. Mehmet Sükrü Sever and Raymond Vanholder. 2009. Myoglobinuric Acute Kidney Failure. https://link.springer.com/chapter/10.1007/978-3-540-69441-0_38

3. Al-Rasbi S, Al-Maqbali JS, Al-Farsi R, Al Shukaili MA, Al-Riyami MH, Al Falahi Z, Al Farhan H, Al Alawi AM. Myocarditis, Pulmonary Hemorrhage, and Extensive Myositis with Rhabdomyolysis 12 Days After First Dose of Pfizer-BioNTech BNT162b2 mRNA COVID-19 Vaccine: A Case Report. https://amjcaserep.com/abstract/full/idArt/934399

4. Elias C, Cardoso P, Gonçalves D, Vaz I, Cardoso L. Rhabdomyolysis Following Administration of Comirnaty. https://www.ejcrim.com/index.php/EJCRIM/article/view/2796

5. Hakroush S, Tampe B. Case Report: ANCA-Associated Vasculitis Presenting With Rhabdomyolysis and Pauci-Immune Crescentic Glomerulonephritis After Pfizer-BioNTech COVID-19 mRNA Vaccination. https://www.frontiersin.org/articles/10.3389/fimmu.2021.762006/full

6. Mahmoud Nassar, Howard Chung, Yarl Dhayaparan, Andrew Nyein, Bryan Jose Acevedo, Celestin Chicos, David Zheng, Mathieu Barras, Mahmoud Mohamed, Mostafa Alfishawy, Nso Nso, Vincent Rizzo, and Eben Kimball. 2021. COVID-19 vaccine induced rhabdomyolysis: Case report with literature review. https://www.sciencedirect.com/science/article/pii/S1871402121001880

7. Kamura Y, Terao T, Akao S, Kono Y, Honma K, Matsue K. Fatal thrombotic microangiopathy with rhabdomyolysis as an initial symptom after the first dose of mRNA-1273 vaccine: A case report. https://www.sciencedirect.com/science/article/pii/S1201971222001072

8. Ajmera KM. 2021. Fatal Case of Rhabdomyolysis Post-COVID-19 Vaccine. https://www.dovepress.com/fatal-case-of-rhabdomyolysis-post-covid-19-vaccine-peer-reviewed-fulltext-article-IDR

9. Salter B, Jessome M, Tarnopolsky M, Yousuf H. 2022. Lien possible entre rhabdomyolyse et vaccin anti-SRAS-CoV-2 à ARNm chez une patiente porteuse d’une mutation du gène RYR1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967437/ Possible association between rhabdomyolysis and mRNA SARS-CoV-2 vaccination in a patient with RYR1 gene mutation. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863193/

10. Mack M, Nichols L, Guerrero DM. 2021. Rhabdomyolysis Secondary to COVID-19 Vaccination. https://www.cureus.com/articles/59492-rhabdomyolysis-secondary-to-covid-19-vaccination#!/

11. Faissner S, Richter D, Ceylan U, et al. 2022. COVID-19 mRNA vaccine induced rhabdomyolysis and fasciitis. https://link.springer.com/article/10.1007/s00415-021-10768-3

12. Cirillo E, et al. 2022. Case Report: Severe Rhabdomyolysis and Multiorgan Failure After ChAdOx1 nCoV-19 Vaccination. https://www.frontiersin.org/articles/10.3389/fimmu.2022.845496/full

13. Tan A, Stepien KM, Narayana STK. Carnitine palmitoyltransferase II deficiency and post-COVID vaccination rhabdomyolysis. https://academic.oup.com/qjmed/article/114/8/596/6237944

14. Gelbenegger G, Cacioppo F, Firbas C, Jilma B. 2021. Rhabdomyolysis Following Ad26.COV2.S COVID-19 Vaccination. https://www.mdpi.com/2076-393X/9/9/956

15. Plotkin E, Bernheim J, Ben-Chetrit S., et al. 2000. Influenza vaccine – a possible trigger of rhabdomyolysis induced acute renal failure due to the combined use of cerivastatin and bezafibrate.

16. Mathia S, Rudigier LJ, Kasim M and Kirschner KM. 2018. A dual role of miR-22 in rhabdomyolysis-induced acute kidney injury. https://onlinelibrary.wiley.com/doi/10.1111/apha.13102

17. Kang YG. 2023. MicroRNA-22 Regulates the Pro-inflammatory Responses and M1 Polarization of Macrophages by Targeting GLUT1 and 4-1BBL. https://www.hindawi.com/journals/jir/2023/2457006/

18. Ogura Y, et al. 2014. Potential amelioration of upregulated renal HIF-1-endothelin-1 system by landiolol hydrochloride in a rat model of endotoxemia. https://www.sciencedirect.com/science/article/pii/S0024320514004809

19. Report on the Deliberation Results April 18, 2022. Pharmaceutical Evaluation Division, Pharmaceutical Safety and Environmental Health Bureau, Ministry of Health, Labour and Welfare. Brand Name Nuvaxovid Intramuscular Injection. Non proprietary Name Recombinant Coronavirus (SARS CoV 2) Vaccine. Applicant Takeda Pharmaceutical Company Limited

20. Stano F, Brindicci G, Monno R, Rizzo C, Ghezzani F, Carbonara S, et al. 2009. Aeromonas sobria sepsis complicated by rhabdomyolysis in an HIV-positive patient: case report and evaluation of traits associated with bacterial virulence. https://www.sciencedirect.com/science/article/pii/S120197120801494X

21.

22. Baumgarten AJ, et al. 2007. Molecular Analysis of Xenograft Models of Human Cancer Cachexia – Possibilities for Therapeutic Intervention. https://cgp.iiarjournals.org/content/4/3/223.long

23. Cramer Z, et al. 2018. eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways. https://www.nature.com/articles/s41598-018-26625-9

24. K. E. Thorp, James A. Thorp, Elise M. Thorp. 2022. COVID-19 and the Unraveling of Experimental Medicine - Part III. https://www.researchgate.net/publication/360292717_COVID-19_and_the_Unraveling_of_Experimental_Medicine_-_Part_III

25. Robert W. Chandler. April 2023. Report 67: Histopathology Series Part 4b – Rhabdomyolysis – a.k.a., “Jellied Muscle” – After mRNA Gene Therapy Injections. https://dailyclout.io/report-67-part-4b-rhabdomyolysis-a-k-a-jellied-muscle-after-mrna-gene-therapy-injections/

26. Kimura M, Niwa J-I and Doyu M. 2022. Recurring Weakness in Rhabdomyolysis Following Pfizer–BioNTech Coronavirus Disease 2019 mRNA Vaccination. https://www.mdpi.com/2076-393X/10/6/935/htm#B15-vaccines-10-00935

27. https://poisonfluoride.com/phpBB3/viewtopic.php?f=66&t=5645&p=6474#p6474

28. Regunath H, et al. 2016. A Case of Fatal Serotonin Syndrome–Like Human Rabies Caused by Tricolored Bat–Associated Rabies Virus. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889760/