Parkinson's Disease after Pfizer jabs most likely due to Endotoxin in every vial
Pfizer reported numerous cases of Parkinson's Disease after its jabs. Recent research shows this is connected with Diabetes. Both are caused by Endotoxin.
In a recent article I wrote about Endotoxin in Pfizer jabs being known to readily cross the Blood-Brain-Barrier and target Microglia, causing many of the common Adverse Events reported by hundreds of millions of Jabbees.1
Endotoxin also damages other types of Brain cells, including Astrocytes.
Here is a lovely picture of Microglia (Green) interacting with Neurons (Red).2
Microglia are usually in a resting state (M2), but in Parkinson's disease can enter M1 state due to the presence of α-synuclein aggregates. The M1 microglia release pro-inflammatory factors, including TNFα, interleukin (IL)-1β and IL-6, which can cause Motor Neurons to die. This is due to the known epigenetic effects of Endotoxin.3
Dying cells can release factors to increase the activation of M1 microglia, leading to a positive feedback loop which causes continually increasing cell death.
α-Synuclein aggregation leads to dopaminergic neuronal cell death through disruption of Mitochondrial function.
The Substantia Nigra has a high density of Endotoxin targeted Microglia and is particularly sensitive to a challenge with Endotoxin.4
Pfizer reports of Parkinson’s Disease
To April 2022, Pfizer reported 798 different “Nervous system disorders” plus numerous serious effects under “General disorders and administration site conditions” including the following numbers of cases for a sample of conditions I have selected, after their jabs.5
Tremor 10,748
Resting tremor 21
Balance disorder 4,497
Movement disorder 2,736
Gait inability 1,678
Bradykinesia 197
Parkinson’s disease 105
Parkinsonism 44
Parkinsonian gait 6
Parkinsonian rest tremor 4
Cogwheel rigidity 4
Parkinsonian crisis 1
Vascular parkinsonism 1
Link to Insulin and Diabetes
Pfizer has thousands of cases of Diabetes listed in its Adverse Event reports, spread under 35 different headings.
Insulin Resistance is a pathological hallmark in the brain of Parkinson’s Disease sufferers.
A recent paper shows that when Endotoxin was injected into the right striatum of Male Wistar Rats, it predictably impaired motor performance of the animals, and increased the levels of α-synuclein and Toll-like Receptor 4 (TLR4). Endotoxin also reduced mRNA levels of IRS1 and IRS2 and enhanced GSK3β mRNA and protein, indicating the development of Insulin Resistance.6
The good news is that administration of Insulin reduced the Brain Damage caused by Endotoxin in the Rats.
Updating 31 March 2024, thanks to an alert by Mathew Aldred.
Chaugu Zheng and coworkers have studied the Gut-Brain axis of nematodes and fed them different types of Bacteria, including E. coli.7
Their graphical abstact:
The authors emphasize the need to do further experiments to see if their work extends to mammals, but the suggestion that excess Vitamin B12 is a factor in Parkinson’s disease and that Propionate can help alleviate neurodegeneration is going to stimulate much discussion.
Endotoxin generates Quinolinic acid, “the inescapable neurotoxin”
A nice review by an Australian researcher8 shows that Endotoxin creates Quinolinic Acid which acts as a Neurotoxin, Gliotoxin, Proinflammatory mediator, Pro-oxidant molecule and can alter the integrity and cohesion of the Blood–Brain Barrier.
Quinolinic Acid is linked to Alzheimer’s disease, HIV-associated neurocognitive disorders, Parkinson’s disease, Motor Neuron diseases, Huntington’s disease, Multiple Sclerosis and major psychiatric disorders. So we can expect to find more cases of these devastating diseases resulting from the Pfizer jabs.
Update 18 May 2024
Prompted by and excellent review of HMGB1 by my friend Moriarty9 that shows how so many diseases are linked to transport and binding with toxins, including Endotoxin and viral Spike, there has been an explosion in research linking this protein to Parkinson’s Disease.10
Update October 2024
Endotoxin expert Etheresia Pretorius is investigating LBP for Parkinson’s patients.11
Questions Arising
Do Women show different Parkinson’s Disease compared to Men?
How long will it take for Parkinson’s Disease caused by the contaminated mRNA jabs to be correctly diagnosed and compensated?
Are there more than a handful of politicians who care?
https://commons.wikimedia.org/wiki/File:Microglia_and_neurons.jpg
Perry V H. 2012. Innate Inflammation in Parkinson’s Disease. Cold Spring Harb Perspect Med 2012;2:a009373
Pfizer 2022. APPENDIX 2.1 Cumulative Number of Case Reports (Serious and Non-Serious, Medically Confirmed and Non Medically-Confirmed) from Post-Marketing Data Sources, Overall, by Sex, Country, Age Groups and in Special Populations and Summary Tabulation by Preferred Term and MedDRA System Organ Class BNT162B2 - ALL Reporting Period: Through 15-APR-2022 FOI-3727
Hemmati F, et al. 2013. Insulin and toll-like receptor 4 interaction in the rat model of Parkinson’s disease induced by lipopolysaccharide. https://www.researchsquare.com/article/rs-2657373/v1
Chenyin Wang, Meigui Yang, Dongyao Liu, Chaogu Zheng. 2024. Metabolic rescue of α-synuclein-induced neurodegeneration through propionate supplementation and intestine-neuron signaling in C. elegans. https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00193-1
Guillemin GJ. 2012. Quinolinic acid, the inescapable neurotoxin https://febs.onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2012.08485.x
Khairiah Razali, Wael M. Y. Mohamed. 2023. High-Mobility Group Box 1 (HMGB1) Protein in Parkinson's Disease Research: A 10-Year Bibliometric Analysis. https://www.imrpress.com/journal/JIN/22/4/10.31083/j.jin2204087/htm
Pretorius E, Page MJ, Mbotwe S, Kell DB (2018) Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease. PLoS ONE 13(3): e0192121. https://doi.org/10.1371/journal.pone.0192121
I have just added Quinolinic Acid as one of the major toxins liberated inside the Brain as a result of Endotoxin opening the Neurotoxic Kynurenine pathway, extending the number of Neurodegenerative diseases we can expect from Pfizer.
I treat patients w PD. 2 things I have observed - some of them have started to progress rapidly and some of them can’t tolerate anymore meds due to low blood pressure. Those reported side effects are out how many administered doses/ subjects?