20 Comments

Thank you. Geoff, so much for discussing PRIONS and CJD.

I know about prion-like domains in the spike protein (a la Tetz) to facilitate affinity with the ACE2 receptor, and have just learned about Christie Grace, who writes about LNPs (https://christielauragrace.substack.com/p/lnp-liquid-nano-phantasmagoria).

This science is way over my head, but I am trying:  "...A 15 kDa proteinase K (PK)-resistant Prion that was detected after 17 rounds of Protein Misfolding Cyclic Amplification (PMCA) which uses cycles of sonication and incubation to grow the Prions."  

Dumbo  queries:  Is this prion material BOTH in the spike and the LNPs?  A double blow? And how to degrade prions?

Huge thanks for your terrific research!

P.S.  Apologies if I am repeating myself, but, please, do you know about any PEG-FREE colonoscopy preps?  

Expand full comment
author

Hi Sally. I did not reproduce discussion of the Spike Protein coding containing sequences that might lead to Prions, covered elsewher. The EMA apparently was more concerned about contamination from the broth used to produce bulk RNA and the Proteinase K used to breakdown unwanted material from the brew. We need urgent toxicology of all compounds used to form LNPs.

The US government provides no information on POPG at the Chemical Toxicogenomics Database http://ctdbase.org/detail.go?type=chem&acc=C060037

I don't know anything about colonoscopy preps, sorry.

Expand full comment
Jan 24, 2023Liked by GeoffPainPhD

Another intriguing article, Geoff, thank you.

Sally, do you happen to remember who wrote about prion-like domains facilitating affinity with ACE2? That's an interesting point I'd like to look at more.

Expand full comment

Delighted to send...

From 2020 http://hmi-us.com/publications/sars-cov-2-prion-like-domains-in-spike-proteins-enable-higher-affinity-to-ace2.htmlSARS-CoV-2 Prion-Like Domains in Spike Proteins Enable Higher Affinity to ACE2

Publication Type Journal article AuthorsGeorge TetzVictor Tetz 

Abstract Currently, the world is struggling with the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Prion-like domains are critical for virulence and the development of therapeutic targets; however, the prion-like domains in the SARS-CoV-2 proteome have not been analyzed. In this in silico study, using the PLAAC algorithm, we identified the presence of prion-like domains in the SARS-CoV-2 spike protein. Compared with other viruses, a striking difference was observed in the distribution of prion-like domains in the spike protein, since SARS-CoV-2 was the only coronavirus with a prion-like domain found in the receptor-binding domain of the S1 region of the spike protein. The presence and unique distribution of prion-like domains in the SARS-CoV-2 receptor-binding domains of the spike protein is particularly interesting, since although the SARS-CoV-2 and SARS-CoV S proteins share the same host cell receptor, angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 demonstrates a 10- to 20-fold higher affinity for ACE2. Finally, we identified prion-like domains in the α1 helix of the ACE2 receptor that interact with the viral receptor-binding domain of SARS-CoV-2. Taken together, the present findings indicate that the identified PrDs in the SARS-CoV-2 receptor-binding domain (RBD) and ACE2 region that interact with RBD have important functional roles in viral adhesion and entry.

Expand full comment

Thank you!

Expand full comment

The prion like domains in the chimeric spike are different topics than the topic of Geoff's post.

Regarding prevention- polyphenols and trace minerals in balance help keep proteins in their proper shapes. Dandelion root and leaf, pomegranate peel, fisetin I think. I have a list.

This link shared by Timothy Wiley may suggest avoiding gluten and letting is helpful and having enough vitamin C, bioflavonoids and corticosteroids helps proteins maintain the correct form. Glyphosate is a risk too. And organophosphates.

Expand full comment
Sep 6, 2023Liked by GeoffPainPhD

This is the first time PEG ,was used in vaccines. Therefore an experiment. Why carcinogenicity tests or toxicity studies not required is surely criminal negligence. The discussion on endotoxins and harrms done by contamination of the covid vials is priceless as all the adverse events causing harm were seeing in VAERS Yellow Card of Britain Eu surveillance are what endotoxins do . Why are so many woman in first world nations dying in childbirth or shortly after? Why were woman bleeding excesxively after these covid MRNA jabs. The LNP creates its own list of adverse events. The spike protein as well. .Kevin McKernan has outed plasmid DNA contamination and essentially ignored and the fact Pfizer refuses to give out levels of endotoxins per ml and refused the expensive purification process for endotoxins is very shady and hinges on criminal and cover up by the various governments.

Expand full comment
Feb 8, 2023·edited Feb 8, 2023Liked by GeoffPainPhD

You might have read this paper by Stephanie Senoff and Greag Nigh over a year ago:

"Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-1"

https://newsrescue.com/worse-than-the-disease-reviewing-some-possible-unintended-consequences-of-mrna-vaccines-against-covid-19-international-journal-of-vaccine-theory-practice-and-research/

Dr. Senoff is a treasure--she is full of great information!

Thank you so much. I look forward to more of your articles. The links to Dr. Jessica Rose are really good background. Good Luck!

Expand full comment
author

Yes, thanks very much. I followed both authors on Twitter before my life ban, follow them both now on Gettr and ResearchGate.

https://www.researchgate.net/profile/Stephanie-Seneff

https://www.researchgate.net/profile/Greg-Nigh

https://www.researchgate.net/profile/Geoff-Pain

Expand full comment

Thank you!

Expand full comment

The ban by twitter is criminal cover up. They ban vaccine injuries by the injured yet allow a video of a woman giving a hand job to a dog.

Expand full comment
Jan 24, 2023Liked by GeoffPainPhD

Thank you. I appreciate the link to https://prions.rip research articles on potentially possible treatments? : )

Expand full comment

This is due to the mRNA genetic sequence misreading, with errors in protein synthesis that lead to a creation of harmful proteolytic elements:

https://www.researchgate.net/publication/354153084_Mini_Review_Correspondence_to_BNT162b2_Vaccine_Possible_Codons_Misreading_Errors_in_Protein_Synthesis_and_Alternative_Splicing's_Anomalies

Expand full comment
author

US Military research on molecular mimicry covers all mechanisms of deliberate harm.

Expand full comment

Fascinating article, it greatly adds to my meager knowledge and understanding of all this. One thing I'm curious about....why are the folded proteins a problem? (folded vs. not folded)

Expand full comment
author

Build up of plaque and induction of autoimmune brain destruction.

Expand full comment
RemovedJan 25, 2023Liked by GeoffPainPhD
Comment removed
Expand full comment
author

Thanks very much, will add your work to my reading and viewing lists.

Expand full comment

Very interesting as always!

Expand full comment