Ferroptosis Diseases caused by Endotoxin

Let's look at who is researching this pathway of poisoning.

In my recent post on Pregnancy Loss caused by Endotoxin¹, I pointed to a 2025 paper² from China on Ferroptosis and here I will expand on where that term can lead.

The paper and the complete list of references are behind a paywall, but the authors kindly provide a graphical abstract.

IS = Implantation Site; LPS = LipoPolySaccharide = Endotoxin; Nrf2 = Nuclear factor erythroid 2-related factor 2; GPX4 = Glutathione Peroxidase 4; Fer-1 = Ferrostatin-1; DFO = Deferoxamine; TRF = Transferrin; FPN1 = Ferroportin; FTH1 = Ferritin heavy chain; NCOA4 = Nuclear Receptor Coactivator 4; mESCs = mouse Endometrial Stromal Cells

Ferroptosis is a hot topic

PubMed has 19,319 papers.³

Of those there are 264 papers covering “Ferroptosis Endotoxin”.⁴

There are 396 papers for “Ferroptosis Lipopolysaccharide.⁵

And “Ferroptosis LPS” finds 451 papers.⁶

The US Comparative Toxicogenomics Database (CTD) provides a list of 260 Human Diseases involving Ferroptosis, with numerous disrupted Genes identified and hundreds of references.⁷

CTD links to Kanehisa Labs KEGG Pathway analysis.⁸

Ferroptosis Disease List

Using the CTD as a starting point.

• Abortion, Spontaneous

• Acquired Hyperostosis Syndrome

• Acute erythroleukemia

• Acute Kidney Injury

• Adenocarcinoma

• Adenocarcinoma, Clear Cell

• Adenocarcinoma Of Esophagus

• Adenocarcinoma of Lung

• Adenoma

• Adrenal Gland Neoplasms

• Adrenocortical Carcinoma

• Adrenocortical Carcinoma, Hereditary

• Adrenoleukodystrophy

• Albuminuria

• Alcoholism

• Alzheimer Disease

• Amino Acid Metabolism, Inborn Errors

• Amphetamine-Related Disorders

• Amyotrophic Lateral Sclerosis

• Anemia

• ANEMIA, CONGENITAL, NONSPHEROCYTIC HEMOLYTIC, 6

• Anemia, Hemolytic

• Anemia, hypochromic microcytic

• Anemia, Hypochromic Microcytic, With Iron Overload

• Anemia, Iron-Deficiency

• Anterior Compartment Syndrome

• Aortic Valve, Calcification of

• Arenaviridae Infections

• Arsenic Poisoning

• Arthritis, Experimental

• Arthritis, Rheumatoid

• Asthma

• Ataxia

• Atherosclerosis

• Atypical Mycobacteriosis, Familial, X-Linked 2

• Autism Spectrum Disorder

• Autistic Disorder

• Balkan Nephropathy

• Berylliosis

• beta-Thalassemia

• Blood Coagulation Disorders

• Brain Diseases

• Brain Infarction

• Brain Ischemia

• Breast Neoplasms

• Cadmium Poisoning

• Calcinosis

• Carcinoma

• Carcinoma, Adenoid Cystic

• Carcinoma, Basal Cell

• Carcinoma, Ductal

• Carcinoma, Hepatocellular

• Carcinoma, Non-Small-Cell Lung

• Carcinoma, Ovarian Epithelial

• Carcinoma, Renal Cell

• Carcinoma, Small Cell

• Carcinoma, Squamous Cell

• Carcinoma, Transitional Cell

• Cardiomegaly

• Cardiomyopathies

• Cardiomyopathy, Hypertrophic

• Cardiotoxicity

• Carotid Artery Diseases

• Cell Transformation, Neoplastic

• Central Nervous System Neoplasms

• Cerebral Hemorrhage

• Chemical and Drug Induced Liver Injury

• Cholangiocarcinoma

• Chromosome 17 deletion

• Colitis

• Colonic Neoplasms

• Colorectal Neoplasms

• Congenital atransferrinemia

• CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIn

• Coronary Artery Disease

• Coronary Vessel Anomalies

• Creutzfeldt-Jakob Syndrome

• Cryptorchidism

• Deficiency Diseases

• Dementia

• Demyelinating Diseases

• Depressive Disorder

• Dermatitis, Allergic Contact

• Dermatitis, Contact

• Diabetes Mellitus

• Diabetes Mellitus, Experimental

• Diabetes Mellitus, Type 1

• Diabetes Mellitus, Type 2

• Diabetic Angiopathies

• Diabetic Nephropathies

• Disease Models, Animal

• Disease Progression

• Drug-Related Side Effects and Adverse Reactions

• Dyskinesias

• Dystonia-Parkinsonism, Adult-Onset

• Echinococcosis

• Embryo Loss

• Emphysema

• Endometriosis

• Epilepsy

• Erythema

• Esophageal Neoplasms

• Esophageal Squamous Cell Carcinoma

• Essential Hypertension

• Familial apoceruloplasmin deficiency

• Fatty Liver

• Fibrosis

• Gallbladder Neoplasms

• Gamma-Glutamylcysteine Synthetase Deficiency, Hemolytic Anemia due to

• Gastroparesis

• Gerstmann-Straussler-Scheinker Disease

• Glioma

• Glucose Intolerance

• Glutathione synthetase deficiency

• Granulomatous Disease, Chronic

• Growth Disorders

• Heart Failure

• Heart Failure, Diastolic

• Helicobacter Infections

• Hemangiosarcoma

• Heme Oxygenase 1 Deficiency

• Hemochromatosis

• Hemochromatosis, type 4

• HEMOCHROMATOSIS, TYPE 5

• Hemolysis

• Hepatitis

• Hepatitis, Chronic

• Hepatolenticular Degeneration

• Hepatomegaly

• Hepatorenal Syndrome

• Heredodegenerative Disorders, Nervous System

• Huntington Disease-Like 1

• Hyperferritinemia, hereditary, with congenital cataracts

• Hyperinsulinism

• HYPERMANGANESEMIA WITH DYSTONIA 2

• Hyperplasia

• Hypertension

• Hypokinesia

• IMMUNODEFICIENCY 46

• Infertility, Female

• Infertility, Male

• Inflammation

• Insomnia, Fatal Familial

• Insulin Resistance

• Iron Metabolism Disorders

• Iron Overload

• Ischemia

• Keloid

• Keratosis

• Kidney Diseases

• Kidney Failure, Chronic

• Kuru

• Learning Disabilities

• Leishmaniasis, Visceral

• Lethargy

• Leukemia, Lymphocytic, Chronic, B-Cell

• Leukemia, Megakaryoblastic, of Down Syndrome

• L-FERRITIN DEFICIENCY

• Li-Fraumeni Syndrome

• Liver Cirrhosis

• Liver Cirrhosis, Experimental

• Liver Diseases

• Liver Diseases, Parasitic

• Liver Failure

• Liver Neoplasms

• Liver Neoplasms, Experimental

• Lung Injury

• Lung Neoplasms

• Lymphoma, Non-Hodgkin

• Lymphoma, T-Cell

• Lymphoma, T-Cell, Cutaneous

• Lymphopenia

• Mammary Neoplasms, Animal

• Mammary Neoplasms, Experimental

• Manganese Poisoning

• Mastocytosis, Systemic

• Melanoma

• Menkes Kinky Hair Syndrome

• Mental Retardation, X-Linked 63

• Mesothelioma, Malignant

• Microphthalmos

• Mitochondrial Diseases

• Mouth Diseases

• Mouth Neoplasms

• Multiple Sclerosis

• Myelodysplastic Syndromes

• Myeloproliferative Disorders

• Myocardial Infarction

• Myocardial Ischemia

• Myocardial Reperfusion Injury

• Myoclonic Epilepsies, Progressive

• Nasal Polyps

• Nasopharyngeal Carcinoma

• Necrosis

• Neoplasm Invasiveness

• Neoplasm Metastasis

• Neoplasms, Experimental

• Nephrotic Syndrome

• Nerve Degeneration

• Neurodegenerative Diseases

• Neuroferritinopathy

• Neuroinflammatory Diseases

• Neurotoxicity Syndromes

• Obesity

• Osteoarthritis

• Osteosarcoma

• Ovarian Neoplasms

• Pancreatic Diseases

• Pancreatic Neoplasms

• Papilloma, Choroid Plexus

• Paratuberculosis

• Parkinson Disease

• Pasteurellaceae Infections

• Penile Neoplasms

• Pneumonia

• Polycystic Ovary Syndrome

• Polyploidy

• Precancerous Conditions

• Precursor Cell Lymphoblastic Leukemia-Lymphoma

• Pre-Eclampsia

• Prion Diseases

• Prostatic Neoplasms

• Proteinuria

• Psoriasis

• Pulmonary Disease, Chronic Obstructive

• Pulmonary Emphysema

• Pulmonary Fibrosis

• Reperfusion Injury

• Respiratory Hypersensitivity

• Restless Legs Syndrome

• Retinal Degeneration

• Retinal Diseases

• Rhinitis, Allergic

• Sarcoma

• Schizophrenia

• Scrapie

• Severe Combined Immunodeficiency

• Sezary Syndrome

• Skin Neoplasms

• Small Cell Lung Carcinoma

• Spinal Cord Injuries

• Spinocerebellar Ataxia 17

• Spondylometaphyseal dysplasia, Sedaghatian type

• Spongiform Encephalopathy with Neuropsychiatric Features

• Squamous Cell Carcinoma of Head and Neck

• Starvation

• Status Epilepticus

• Stomach Neoplasms

• Teratozoospermia

• Thrombosis

• Thymoma

• Thyroid Neoplasms

• Urinary Bladder Neoplasms

• Urogenital Neoplasms

• Urologic Neoplasms

• Vascular System Injuries

• Vulvar Lichen Sclerosus

• Weight Loss

• Wilms Tumor

• Wounds and Injuries

Other Substack authors on Ferroptosis.

A quick search found Jessina Graham’s Substack.⁹

I will link to others as they are found if they have mentioned Endotoxin Induction Ferroptosis.

There are many people researching the topic, as I found¹⁰ on X.

1.

2. Yanmei Liu, Yaping Zhou, Binhe Hao, Zining Wu, Min Gao, Ling Liu, Qiang Xia, Kainan Zheng, Shuang Yang, Yaoting Tang, Ming Gong, Cun Feng, Honglu Diao, Yan Tan, Hongtao Zheng. 2024. Inhibition of ferroptosis attenuate lipopolysaccharide-induced early pregnancy loss by protecting against decidual damage of stromal cells. Biochem Biophys Res Commun. 3:736:150904. doi: 10.1016/j.bbrc.2024.150904. https://www.sciencedirect.com/science/article/abs/pii/S0006291X24014402

3. https://pubmed.ncbi.nlm.nih.gov/?term=ferroptosis

4. https://pubmed.ncbi.nlm.nih.gov/?term=ferroptosis+endotoxin

5. https://pubmed.ncbi.nlm.nih.gov/?term=ferroptosis+Lipopolysaccharide

6. https://pubmed.ncbi.nlm.nih.gov/?term=ferroptosis+LPS

7. https://ctdbase.org/detail.go?acc=KEGG%3Ahsa04216&view=disease&sort=diseaseNmSort&type=pathway&dir=asc

8. https://www.kegg.jp/pathway/hsa04216

9. Ferroptic Illnesses: Translating complex biology into bedside-ready diagnostics for ME/CFS, Long COVID, and related syndromes

10. https://x.com/search?q=Ferroptosis&src=typed_query&f=user