4 Comments
author

I will be expanding this article, adding numerous references in the next day or so.

Expand full comment
Mar 3, 2023Liked by GeoffPainPhD

Just came across this study and thought you might appreciate it:

Lustig S, Danenberg HD, Kafri Y, Kobiler D, Ben-Nathan D. Viral neuroinvasion and encephalitis induced by lipopolysaccharide and its mediators. J Exp Med. 1992 Sep 1;176(3):707-12.

"The present study was designed to test the effect of bacterial endotoxin on penetration of viruses into the central nervous system (CNS). As a model we used two neurovirulent viruses that lack neuroinvasive capacity: West Nile virus-25 (WN-25) and neuroadapted Sindbis virus (SVN). ... We suggest that LPS can contribute to virus penetration from the blood into the CNS, a process which turns a mild viral infection into a severe lethal encephalitis. This effect is mediated by soluble factors, and is probably achieved by injury to cerebral microvascular endothelium and modulation of BBB permeability."

Expand full comment

Most interesting & well documented reading, thanks for your work once again!

Expand full comment