Dimethyl Sulfoxide - Wilful Blindness to its Genotoxicity causing Anophthalmia

I was asked whether a little bit of supertoxic DMSO could be a good thing. I am calling for a Global Ban, as happened for Benzene, also once considered "Safe".

Just a short one today, expanding on my first¹ in a series.

What is it like to be born without Eyes?

We know injection of Hamsters with Endotoxin causes that birth defect.²

Did you know use of Chick Embryos is widespread to study Mutagens?

There is no need to request animal protocol approval for the chicken embryo as an experimental model in ovo as they are exempt from the horizontal legislation on the protection of animals used for scientific purposes (2010/63/EU), as well as applicable laws in the United States.³

On the left observe a common defect in Chicks exposed to tiny amounts of DMSO injected on the top of inner shell membrane (membrana papyracea).

DMSO dose boost increased the number of dead embryos, reaching 75% with 35 μL.

The authors were mainly interested in the Liver Damage. They found that:

even the lowest administered DMSO volume could affect hepatocytes at the molecular level causing down-regulation of cytochrome P450 complex (CYP1A5, CYP3A37, CYP3A80).

Updating, have been alerted to another very useful article pointing to DMSO harms.⁴

1.

2. J. C. Lanning, D. R. Hilbelink, and L. T. Chen. 1983. Teratogenic Effects of Endotoxin on the Golden Hamster. Teratogenesis, Carcinogenesis, and Mutagenesis 3: 145-149

3. Lenka Luptakova, Simona Dvorcakova, Zuzana Demcisakova, Lassaad Belbahri, Katarina Holovska and Eva Petrovova. 2021. Dimethyl Sulfoxide: Morphological, Histological, and Molecular View on Developing Chicken Liver. Toxics 9:55. https://www.mdpi.com/2305-6304/9/3/55

4. Disastrous DMSO