Budesonide Inhalation Deaths on FAERS

Described as an "Essential Medicine" Pulmicort among many other brand names, Budesonide has 2 isomers with different effects, as does Thalidomide and ALC-0315. Looking at side effects and Death Toll.

Using the US FAERS database is illuminating as I have noted previously.¹

Now I find that there is a “Contagion Emergency Kit”, apparently renamed from “Covid Emergency Kit” being sold for the use of a single person for US$300.²

It contains Ivermectin, Hydroxychloroquine, Azithromycin (generic Z-Pak™ that I have discussed recently³ ) as well as Budesonide that looks like this:

Picture credit Wikipedia.⁴

The Budesonide in the Kit is inhaled using a liquid Nebulizer and delivered via Face Mask.

Note that Budesonide comes as 2 stereoisomers, like Thalidomide⁵ and the Lipid Nanoparticle chemical ALC-0315⁶.

The 2 Chiral isomers of Budesonide affect the Adverse Events as reported in careful study.⁷ By patch testing 10 patients hypersensitive to Budesonide it was found that 9 of 10 patients reacted to Budesonide S diastereomer and 7 of 9 to the R diastereomer. Pure R and S isomers were supplied by AstraZeneca Sweden and both were found to be sensitizers. The anti-inflammatory effect of the R isomer was found to be twice that of the S isomer.

Budesonide is known to cause Anaphylaxis in some individuals.⁸

Deaths reported to FAERS for Budesonide

FAERS shows 1,010 Deaths, 17,045 cases of Serious Adverse Events (including Deaths) from a total of 28,847 Reports. Cases peaked in 2023.

For the particular brand name Pulmicort, as sold in TWC Contagion Kit, there were 281 Deaths, 6,445 cases of Serious Adverse Events (including Deaths) from a total of 12,416 Reports. Cases peaked in 2021.

Deaths reported to TGA DAEN for Budesonide

In Australia there have been 8 Deaths from 205 case reports sent to TGA DAEN.

Symptoms associated with the Deaths included:

• Abdominal pain

• Adenovirus infection

• Alanine aminotransferase increased

• Anaemia

• Bilirubin conjugated increased

• Bronchospasm

• Chills

• Coagulopathy

• Confusional state

• Constipation

• Cyanosis

• Dermatitis bullous

• Diarrhoea

• Dyspnoea

• Drug ineffective

• Enterococcal bacteraemia

• Face oedema

• Haemophagocytic Lymphohistiocytosis

• Headache

• Hepatic steatosis

• Intracranial Haemorrhage

• Klebsiella bacteraemia

• Mouth ulceration

• Multiple organ dysfunction syndrome

• Neutropenia

• Pulmonary oedema

• Pyrexia

• Rectal haemorrhage

• Sepsis

• Syncope

• Thrombocytopenia

I will have to do further research into the specified causes of Death from Budesonide and will add references later.

UK withdrew use of Budesonide for Covid19

In December 2021 the UK National Health Service, acting on revised guidance from the National Institute for Health and Care Excellence (NICE), announced the withdrawal of Budesonide as a treatment option for the airborne Contagion Covid19.⁹

Happy Easter dear readers.

5 August 2024 Update

FAERS updated their data to 30 June 2024 showing

1,081 Deaths

18,053 cases of Serious Adverse Events (including Deaths)

from a total of 30,835 Reports for Budesonide

1.

2. https://www.twc.health/products/covid-emergency-kit

3.

4. https://en.wikipedia.org/wiki/Budesonide

5. https://en.wikipedia.org/wiki/Thalidomide

6.

7. M Isaksson, M Bruze, J P Lepoittevin, A Goossens. 2001. Patch testing with serial dilutions of budesonide, its R and S diastereomers, and potentially cross-reacting substances. Am J Contact Dermat. 12(3):170-6.

8. C. PIRKER, A. MISˇ I
CC AND P. J. FROSCH. 2003. Angioedema and dysphagia caused by contact allergy to inhaled budesonide. Contact Dermatitis. 49: 77–79. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.0105-1873.2003.00169.x

9. https://www.cas.mhra.gov.uk/ViewandAcknowledgment/ViewAlert.aspx?AlertID=103185