Broken Bones from Endotoxin in Jabs
Pfizer reports of Bone fractures all over the body can be traced to Endotoxin disruption of Phosphate chemistry
My friend Rob pays particular attention to the surge in Sports injuries in jabbed previously healthy young people. He pointed out a surge in bone breaks that he observed worldwide, so I think it is worth a delve.
Let’s look at a skeleton that shows some of the Bones reported broken as Adverse Events. Just Pfizer because I have their June 2022 report handy.
Pfizer Bone Fractures and Damage
In the Pfizer trial, 1 case of Facial Bone Fracture was reported in the 16-17 years old subset to 20 December 2020.
Pfizer reported the following Process 2 post-marketing case numbers to June 2022:
Acetabulum fracture 3; Alveolar osteitis 4; Ankle deformity 1; Ankle fracture 26; Ankylosing spondylitis 200; Arachnodactyly 1; Arterial tortuosity syndrome 1; Arthralgia 121,356; Arthritis 2,754; Arthritis allergic 2; Arthritis bacterial 26; Arthritis enteropathic 1; Arthritis infective 25; Arthritis reactive 287; Articular calcification 7; Atypical femur fracture 2;
Benign bone neoplasm 1; Bone atrophy 1; Bone cancer 7; Bone cancer metastatic 2; Bone cyst 6; Bone deformity 6; Bone demineralisation 1;Bone density abnormal 2; Bone density decreased 5; Bone density increased 1; Bone development abnormal 1; Bone disorder 84; Bone erosion 1; Bone formation increased 1; Bone hypertrophy 1; Bone infarction 2; Bone lesion 9; Bone loss 3; Bone marrow myelogram abnormal 2; Bone marrow transplant 2; Bone neoplasm 26; Bone pain 4,671; Bone swelling 129; Brachydactyly 2;
Camptocormia 3; Cerebral calcification 3; Cervical vertebral fracture 4; Chondrocalcinosis 24; Chondrocalcinosis pyrophosphate 20; Choreoathetosis 3; Chronic recurrent multifocal osteomyelitis 1; Clavicle fracture 33; Cleft lip and palate 4; Cleft palate 4; Clubbing 4; Compression fracture 11; Congenital jaw malformation 1; Craniofacial fracture 1; Craniofacial injury 4; Craniosynostosis 2; Cutis laxa 1;
Degenerative bone disease 7; Dermatomyositis 96;
Ectrodactyly 1; Elbow deformity 1; Enchondromatosis 1; Epiphyseal injury 1; Epiphyses premature fusion 1; Exostosis 22;
Facial bones fracture 69; Femoral neck fracture 38; Femur fracture 48; Fibula fracture 7; Finger deformity 50; Foot deformity 52; Foot fracture 36; Forearm fracture 1; Fracture 110; Fractured coccyx 2; Fracture displacement 2; Fractured sacrum 3; Fractured skull depressed 1; Fracture pain 6;
Gout 532; Gouty arthritis 20;
Hand deformity 40; Hand fracture 22; Haemangioma of bone 1; Head deformity 5; Hip deformity 2; Hip fracture 50; Humerus fracture 20; Hypophosphataemia 18; Hypophosphatasia 1
Immune-mediated arthritis 4; Interspinous osteoarthritis 1; Intervertebral discitis 27; Intervertebral disc injury 3; Intervertebral disc protrusion 216;
Jaw clicking 23; Jaw disorder 95; Jaw fracture 21; Joint ankylosis 61; Juvenile idiopathic arthritis 29; Juvenile psoriatic arthritis 1;
Knee deformity 5; Kyphosis 6;
Lower limb fracture 36; Lumbar vertebral fracture 14;
Macrocephaly 1; Mandibular mass 5; MELAS (Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like episodes) 1; Metastases to bone 15; Medial tibial stress syndrome 15; Microcephaly 1; Mitochondrial encephalomyopathy 1; Mitochondrial myopathy 2; Mitochondrial myopathy acquired 1; Multiple fractures 12;
Nodal osteoarthritis 13;
Open fracture 3; Osteitis 95; Osteoarthritis 552; Osteochondritis 5; Osteochondroma 1; Osteochondrosis 7; Osteogenesis imperfecta 2; Osteolysis 10; Osteoporotic fracture 5; Osteonecrosis 24; Osteonecrosis of jaw 4; Osteomyelitis 42; Osteomyelitis acute 3; Osteomyelitis bacterial 1; Osteomyelitis chronic 3; Osteoporosis 55;
Paraneoplastic arthritis 2; Patella fracture 9; Pathological fracture 6; Pelvic fracture 25; Periprosthetic fracture 2; Periostitis 16; Pituitary-dependent Cushing's syndrome 2; Polydactyly 2;
Radius fracture 11; Resorption bone increased 2; Rheumatoid arthritis 1,364; Rib fracture 99;
Scapula fracture 3; Scoliosis 27; Seronegative arthritis 51; Shoulder deformity 9; Skull fracture 18; Skull fractured base 11; SLE arthritis 6; Spinal compression fracture 23; Spinal deformity 15; Spinal disorder 83; Spinal fracture 41; Spinal osteoarthritis 132; Spondylitis 105; Spondyloarthropathy 12; Spondylolisthesis 7; Spondylolysis 3; Stress fracture 8; Sternal fracture 6; Syndactyly 4;Synovitis 129;
Thoracic vertebral fracture 14; Tibia fracture 12; Tooth demineralisation 1; Tooth discolouration 15; Tooth disorder 112; Tooth erosion 5; Tooth fracture 58; Tooth impacted 5; Tooth resorption 2; Tooth loss 41; Tooth socket haemorrhage 3; Torus fracture 2; Traumatic fracture 2;
Ulna fracture 5; Upper limb fracture 67;
Vascular calcification 8;
Wrist fracture 21;
Comparative Toxicogenomics Database
The US government Comparative Toxicogenomics Database, which was offline for updating when I drafted this article, provides a duplicated list of 1,016 Endotoxin Musculoskeletal Diseases with literature references. Here are the first 50 lines.
Culled that down and compared with the Pfizer reports of Adverse Events, w find nearly all of the diseases above match the CTD.
Hypophosphatasia caused by Endotoxin
A great place to start is a review by Millan and Whyte discussing the factors that can interfere with Bone formation, resorption and Fracture.1
Tissue-Non-Specific Alkaline Phosphatase (TNAP, or TNSALP), is encoded by the ALPL gene and is inhibited by Inorganic PyroPhosphate (PPi).
TNAP helps to detoxify Endotoxin.
Some Hypophosphatasia (HPP) patients suffer Calcium PyroPhosphate Dihydrate (CPPD) crystal deposition (Chondrocalcinosis), PPi Arthropathy including attacks of Pseudogout, or sometimes Calcific Periarthritis. Odonto-HPP is diagnosed when the only clinical abnormality is Dental disease.
HPP patients have high Pyridoxal-50-phosphate levels.
Endotoxin is known to result in circulating Calcium levels in Osteoporosis sufferers.2
Animal models show Calcium levels are through T-type calcium channels activated by the NFκB/ET-1 signaling pathway.3
Endotoxin stimulation of various pro-inflammatory cytokines and mediators, such as Tumor Necrosis Factor (TNF)-α, Interleukin (IL)-1, and Prostaglandin E2 (PGE2), produced by macrophages and T-lymphocytes. These cytokines stimulate Receptor Activator of Nuclear Factor Kappa-Β Ligand (RANKL) and maturation and differentiation of Osteoclasts and bone loss.
This Figure4 shows the importance of Interleukin-65 in Bone Fracture
Endotoxemia has been observed in Ankle fractures.6
Endotoxin disrupts ATPASE.7
Millan JL and Whyte MP. 2015. Alkaline Phosphatase and Hypophosphatasia. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824800/
Aziz I, et al. 2016. Endotoxin and bone turnover markers in postmenopausal women with and without osteoporosis. https://irep.ntu.ac.uk/id/eprint/30599/
Zhang L, et al. 2014. Lipopolysaccharides upregulate calcium concentration in mouse uterine smooth muscle cells through the T-type calcium channels. https://www.spandidos-publications.com/ijmm/35/3/784
Tanaka T, et al. IL-6 in Inflammation, Immunity, and Disease. https://cshperspectives.cshlp.org/content/6/10/a016295
Buttenschoen K, et al. 2000. Translocation of Endotoxin and Acute-Phase Proteins in Malleolar Fractures. https://journals.lww.com/jtrauma/abstract/2000/02000/translocation_of_endotoxin_and_acute_phase.8.aspx
Zhang T, et al. 2012. Inhibition of Na/K-ATPase promotes myocardial tumor necrosis factor-alpha protein expression and cardiac dysfunction via calcium/mTOR signaling in endotoxemia. https://link.springer.com/article/10.1007/s00395-012-0254-8