Acetaldehyde from Ethanol in Pfizer jabs causing Batch Lethality variation?
Pfizer jabs with Phosphate buffer had EU specification allowing up to 5000 parts per million Ethanol in finished product after wrapping mRNA in LNPs. Cancer Hazard from Oxidation forming Acetaldehyde?
As I and others have highlighted, the mRNA jabs are inherently dangerous due to the GMO mRNA and the other ingredients including Sugar and the 4 chemicals used to make the Lipid Nanoparticles (LNPs) and the Endotoxin from E Coli.1
During manufacture, the 4 precursors of LNPs are dissolved in Ethanol and the mRNA is dissolved in acidified water. Then the 2 liquid streams are forced together in a narrow tube with diluent water to increase the pH and encourage formation of cationic LNPs and anionic mRNA to bind together - a process that is allowed to fail 50% of the time, leaving free mRNA in the jabs.
As shown in this leaked European Medicines Agency specification, they were prepared to pay BioNTech billions of Euros for this mess, with up to 5,000 ppm Ethanol residue (0.5% or 5000 mg/Litre). This appears to be an arbitrary EU upper limit.2
So we need the results of every Lot or Batch tested under Procedure TM100010581 to find out how much Ethanol was in the product when put into vials.
Hypersensitivity to Ethanol
The literature is sparse. Extreme Ethanol sensitivity presenting with Coma is reported behind a paywall.3 Other symptoms rported include:
Flushing, Tachycardia, Weakness, Fatigue, and “other dysphoric symptoms”.
Acetaldehyde content of Jabs Unknown
I am prepared to wager that Pfizer in America and BioNTech in Germany both filled their vials in Air, rather than an inert gas like Nitrogen or Argon.
If I am right, we can expect oxidation of some of the Ethanol to form Acetaldehyde and further derivative products, including Ethyl Hemiacetal and 1,1-Diethoxyethane (also known as Acetal and a host of synonyms, see ball and stick model4 ) over time.5
The oxidation will vary depending on light exposure and the possible catalytic effects of the vial surface.
Unsafe levels of Acetaldehyde and Acetal have been identified in various hand sanitizers.6
Any Acetaldehyde formed in the vial will react with the mRNA to form adducts, preventing full transcription of the mRNA, resulting in lower molecular weight products observable using various chromatographic techniques.7
Ethanol in Jabs linked to instability of LNPs
A paper, unfortunately behind a paywall, links Ethanol residue in mRNA jabs to degradation of the LNPs.8
Acetaldehyde in Deliberate Human DNA mutation
Pfizer vials contain all you need to deliberately Mutate Human DNA.
In 2006 Stein and coworkers used SV40 promoter and Acetaldehyde 1,N2-propanodeoxyguanosine adduct diastereomers in E. coli Plasmid for genotoxicity studies of role in Aging and Cancer.9
Serdons K, et al. The Presence of Ethanol in Radiopharmaceutical Injections. https://jnm.snmjournals.org/content/49/12/2071
Lerman B and Bodony R. 1991. Ethanol Sensitivity. https://www.annemergmed.com/article/S0196-0644(05)81390-3/pdf
1,1-diethoxyethane. https://pubchem.ncbi.nlm.nih.gov/compound/1_1-Diethoxyethane
Scheithauer A et al. 1H- and 13C-NMR spectroscopic study of chemical equilibria in the system acetaldehyde + water. 2014. https://aiche.onlinelibrary.wiley.com/doi/abs/10.1002/aic.14623
Manuel CS et al. 2022. Presence of unsafe chemical impurities, accelerated evaporation of alcohol, and lack of key labeling requirements are risks and concerns for some alcohol-based hand sanitizers and dispenser practices during the COVID-19 pandemic. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0265519
Anindita De and Young Tag Ko. 2022. Why mRNA-ionizable LNPs formulations are so short-lived: causes and way-out. https://www.tandfonline.com/doi/full/10.1080/17425247.2023.2162876
Stein S, et al. 2006. Genotoxicity of acetaldehyde- and crotonaldehyde-induced 1,N2-propanodeoxyguanosine DNA adducts in human cells. https://www.sciencedirect.com/science/article/abs/pii/S1383571806001045
I once did a big review of the toxic effects of aldehydes, especially on the brain, sharing in case it useful: https://www.outthinkingparkinsons.com/articles/dopamine-aldehyde?rq=aldehydes
So in many ways batch variation could be caused by poor manufacturing, (as Sasha Latypova has highlighted), as well as little or no quality control. All originally in an attempt to rush out the batches and maximise profits. Then there is the added factor of transportation and storage before use, the early stipulation for "extremely low temperatures" suddenly seemed to disappear, and it almost became a case of, "stick it in the fridge and use as necessary". Perhaps those batches which were stored properly kept more mRNA intact and were therefore more dangerous to the vaccinee, whereas others may have simply degraded and become almost useless (and less dangerous!)