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Inflammation is a complex process that involves the activation of immune cells in response to tissue injury or infection.

In the central nervous system (CNS), inflammation can occur in response to a variety of stimuli, including infection, trauma, and neurodegenerative diseases.

One of the key components of CNS inflammation is the activation of blood vessels in the brain. This activation is known as neurovascular coupling and is thought to play an important role in regulating blood flow to regions of the brain that are active during cognitive or sensory tasks.

Inflammation can modulate neurovascular coupling by altering the response of blood vessels to neuronal activity.

This can lead to changes in cerebral blood flow, which can have important implications for brain function.

In addition to its effects on neurovascular coupling, inflammation can also contribute to the development of various CNS diseases, such as stroke, multiple sclerosis, & Alzheimer's disease.

In these conditions, inflammation can lead to damage to blood vessels and neurons, which can result in cognitive and motor deficits.

Interventions that target inflammation in the CNS have the potential to improve outcomes in these diseases.

For example, drugs that inhibit the activity of immune cells or reduce inflammation in the brain have shown promise in preclinical studies and clinical trials.

Inflammation plays a critical role in modulating CNS vessel activation & is a promising target for intervention in a range of neurological diseases...

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