Rapid Liver Failure after Pfizer jabs most likely due to miR-155 upregulation by Endotoxin
Huge numbers of jabbees have suffered Liver Failure within days of getting their mRNA toxic soup. Endotoxin will beat synthetic Spike or LNP components.
In a previous article I showed how Heart Damage caused by mRNA jabs can be explained by the catalytic effects of upregulation of the microRNA molecule known as miR-155.1
Liver Failure during the Trial
Pfizer knew from its clinical trial and first 90 days of mass jabbing that severe and Fatal Liver Failure was a clear signal of systemic assault by its product with 70 cases and 5 Deaths.2 The median onset of the Liver damage was just 3 days!
Many cases of jab induced Liver Failure are likely hidden under “Sepsis” and “Multi-Organ Failure”.
Pfizer Liver Damage cases have recently been reported here on Substack.3
Liver Failure reported by Pfizer after mass Jabbing
Pfizer uses 122 different, often vague, descriptors of Liver Damage including 35 different names for Hepatitis under the heading “Hepatobiliary disorders” to deliberately hide tens of thousands of victims. Here I show increases (designated with >) of cases reported by Pfizer between 2021 compared with its PSUR3 report in 2022.45
Selected Examples with case numbers include:
Jaundice 308 > 341
Liver disorder 299 > 320
Hepatitis 230 > 258
Hepatic cytolysis 226 > 242
Hepatic pain 224 > 253
Cholelithiasis 173 > 193
Portal vein thrombosis 161 > 171
Autoimmune hepatitis 151 > Deleted in Report PSUR3
Hepatic steatosis 135 > 155
Hepatomegaly 118 > 128
Cholestasis 115 > 122
Hepatitis acute 106 > 113
Liver injury 101 > 106
Hepatic failure 97 > 104 Acute hepatic failure 34 > 39
Liver transplant rejection 3
and the list goes on and on and on…
Endotoxin in Pfizer jabs catalyzes Liver Failure
In 2007, Endotoxin was shown to cause Fatal Liver Damage in E-miR-155 transgenic mice and their wild-type littermates.6
Death was enhanced and hastened by administration of D-Galactosamine.
Rats given Galactosamine7 show elevated activities of serum Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), levels of Triglycerides, total Cholesterol, Lipid-peroxidation and reduction in the levels of serum total proteins, albumin and cellular Glutathione S-transferase (GSH). Galactosamine increased the nuclear translocation of NFκB and elevated iNOS protein expression, Tumor Necrosis Factor (TNF-α), Interferon (IFN-γ), Inflammatory Interleukins IL-1β, IL-6, IL-12, IL-18 and decreased anti-inflammatory IL-10 mRNA expressions.8
The mechanism of Endotoxin/Galactosamine Liver toxicity involves attack of the Kupffer cells9 by Endotoxin attachment to Toll-like receptor 4 (TLR4).10
It is known that Tumor Necrosis Factor (TNF-α) enhances the Liver toxicity of miR-155, which is thought to directly target transcript coding for several proteins Fas-Associated Death Domain protein (FADD), IκB kinase ε (IKKε), and the receptor (TNFR superfamily)-interacting serine-threonine kinase 1 (Ripk1).
Eμ-miR-155 transgenic mice produced higher levels of TNF-α when exposed to Endotoxin, promoting the positive feedback loop (Tili 2007).
Wikipedia has good coverage of miR-155 studies for experts to peruse.11
Questions Arising
Do the mRNA jabs upregulate Galactosamine in Humans, thereby enhancing the Lethality of the Endotoxin miR-155 pathway?
Do the jabs alter the Uridine pathways in Humans?
Are there racial differences in Liver damage by the jabs that might relate to Galactose pathways?
Will Women suffer more Liver damage and Fatality than Men related to Galactosamine involvement in Follicle Stimulating Hormone and Luteinizing Hormone?
Paracetamol and Endotoxin destroy your Liver
Acetaminophen (Tylenol) and Paracetamol (Panadol) are the same medication. Both drugs are chemically the same. The drug is called Acetaminophen in the United States and Japan, and Paracetamol in Europe and most of the rest of the world12 including Australia. Found a nice paper showing how Paracetamol and Endotoxin (LPS) both destroy your Liver, but do it better together as shown in their Figure 4.13
So I raised the issue on Twitter (X) of what effect this drug had in Covid19 Jab Clinical Trials where we know some subjects were given it Before, and After to minimize Fever and other side effects.
Barbara Gehrett, Joseph Gehrett, Chris Flowers and Loree Britt. 2023. Report 51: Liver Adverse Events – Five Deaths Within 20 Days of Pfizer’s mRNA COVID Injection. 50% of Adverse Events Occurred Within Three Days. https://dailyclout.io/report-51-liver-adverse-events
Pfizer 2021. APPENDIX 2.1 Cumulative Number of Case Reports (Serious and Non-Serious, Medically Confirmed and Non Medically-Confirmed) from Post-Marketing Data Sources, Overall, by Sex, Country, Age Groups and in Special Populations and Summary Tabulation by Preferred Term and MedDRA System Organ Class BNT162B2 - ALL Reporting Period: Through 15-APR-2022. FOI-3727.
Pfizer 2022. PSUR3. APPENDIX 2.2: Cumulative and Interval Summary Tabulation of Serious and Non-Serious Adverse Reactions from Post-Marketing Data Sources. BNT162B2. Cumulative Reporting Period: Through 18-JUN-2022. Interval Reporting Period: 19-DEC-2021 Through 18-JUN-2022. Total Number of Cases: 507,683 (Interval) / 1,485,027 (Cumulative). Total Number of Adverse Events (PT): 1,591,026 (Interval) i 4,964,106 (Cumulative)
Esmerina Tili et al. 2007. Modulation of miR-155 and miR-125b Levels following Lipopolysaccharide/TNF-α Stimulation and Their Possible Roles in Regulating the Response to Endotoxin Shock. https://journals.aai.org/jimmunol/article/179/8/5082/111528/Modulation-of-miR-155-and-miR-125b-Levels
https://en.wikipedia.org/wiki/Galactosamine
Joydeep Das et al. 2012. Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2-NFκB pathways. https://www.sciencedirect.com/science/article/abs/pii/S0041008X12000269
https://en.wikipedia.org/wiki/Kupffer_cell
Michaël Maesa, Mathieu Vinkena and Hartmut Jaeschke. 2015. Experimental models of hepatotoxicity related to acute liver failure. https://www.researchgate.net/publication/284810548_Experimental_models_of_hepatotoxicity_related_to_acute_liver_failure
https://en.wikipedia.org/wiki/MiR-155
https://www.emedicinehealth.com/are_acetaminophen_and_paracetamol_the_same/article_em.htm
Jiang J, et al. 2019. Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity. https://www.sciencedirect.com/science/article/pii/S0378427419301377
Coincidentally, I know two people, one a physician, with serious liver injuries from mRNA jabs. The injuries did not, however, manifest within hours of the shots. One nearly died of portal vein thrombosis weeks after a third shot; one was operated on for an infected cyst on his liver and treated for sepsis two years after his second and final mRNA shot ( and that shot was followed by myocarditis, hospitalization, a morphine drip, weeks later.). Now, it is of interest that these two formerly healthy male individuals do not believe their injections caused their unfortunate illnesses, and no VAERS reports were ever made. So, in addition to the smeared out data for hepatic injury reported under myriad labels, there is the unreported factor.