Mantle Cell Lymphoma linked to Endotoxin via CD5

Because it is a rare disease, but known for decades, the older papers provide more useful insights, ruling out linear Jab Plasmid DNA fragment contamination as a cause

Due to the huge media interest in the plight of Magda Szubanski, who bravely discusses her treatment, I thought it useful to delve further into the triggers of Mantle Cell Lymphoma (MCL).

In this post, I focus on one factor, CD5, although there are many other cell types linked.

Mantle cell lymphoma. Notice the irregular nuclear contours of the medium-sized lymphoma cells and the presence of a pink histiocyte. By immunohistochemistry the lymphoma cells expressed CD20, CD5 and cyclin D1 (high power view, H&E)

Photo credit. Gabriel Caponetti 2009.

See my previous article.

Magda Szubanski suffers Mantle Cell Lymphoma

CD5 is a key factor

Here is the US Comparative Toxicogenomics Database (CTD) Summary for CD5.

Please click to expand to view the CD5 synonyms that would have to be chased for a comprehensive review, if only I had time. Perhaps Subscribers would like to help?

You can see that Endotoxin (Lipopolysaccharide) is top of the list.

Also mentioned is Tobacco Smoke, which is full of Endotoxin.

I will make this article a special for paid subscribers who are interested in rare lymphatic cancers.