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Endotoxins in Pfizer jabs mimic Nickel Allergy

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Endotoxins in Pfizer jabs mimic Nickel Allergy

A subset of VAERS reports in people with Nickel allergy show Death, Anaphylaxis, Clots and Heart damage after Pfizer jabs. 93% of the victims are women. NETosis is a common mechanism of harm.

GeoffPainPhD
Feb 25, 2023
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Endotoxins in Pfizer jabs mimic Nickel Allergy

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NETosis is caused by Nickel and Endotoxins

The common toxin entry point for Nickel and Endotoxins is the TLR4 on the surface of various cells. Here I discuss the process of NETosis, a primary mechanism involved in Blood Clotting that can lead to Stroke, Heart Damage and numerous other harms to multiple organs. Do Pfizer Bad Batches contain more Nickel or Endotoxin?

In a previous article I suggested the high frequency of Adverse Reactions to Saline Placebo in jab trials could be caused by Nickel and/or Chromium allergy because stainless steel syringe needles are known to leave shards of metal behind in the arm muscle.

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Pfizer makes DNA template for jab Manufacturing Process 2 for mRNA BNT162b using modified DH10B Escherichia coli.

E Coli produce Endotoxins (also known as LipoPolySaccharides LPS) that cause a plethora of toxic effects on exposure to picogram quantities

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, including:

Anaphylaxis (often Fatal, see below)

Syncope

Thrombotic Thrombocytopenia

Brain damage

Cancer activation and metastasis

Damage to the Hypothalamic–Pituitary–Gonadal (HPG) axis which is primarily responsible for regulating reproductive activity and the release of ovarian hormones in animals and humans, including uterine contractions during Menstruation.

To 15 April 2022, Pfizer reported the following numbers of victims known to them to have suffered:

Anaphylactic reaction 7,214

Anaphylactic shock 1,184

Anaphylactoid reaction 197

Anaphylactoid shock 8

Anaphylactoid syndrome of pregnancy 1

Palpitations 27,157

Tachycardia 22,873

Syncope 13,056

Myocarditis 11,299

Loss of consciousness 7,261

Depressed level of consciousness 1,553

Altered state of consciousness 1,829

Consciousness fluctuating 19

Plus tens of thousands of cases of Heart Damage spread under hundreds of headings.

Endotoxins act on 73 Human genes to cause multiple pathways to inflammation.

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A sample of 1,690 Pfizer VAERS reports for those with Nickel Allergy

My friend Openvaet

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kindly used his data mining skills last year to download Adverse Events reports from the US VAERS database for cases where Nickel allergy was mentioned in the text. Many of these were “Foreign Reports” which have been subsequently edited to remove details.

There were reports for 1,561 Women (93%), 115 Men and 14 where gender was unknown. Women are more frequently allergic to Nickel due to exposure to alloy plated jewelry.

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Here is a record, submitted by Pfizer to VAERS, for a 44 year-old woman from Austria who died of Anaphylactic shock after her Pfizer jab with Batch number EJ6797.

She was jabbed on 19 January 2021 and suffered Anaphylaxis, Flushing, Itching, Exanthema on her face, trunk and forearms, wheals, furry feeling in her tongue and a strange taste 12 minutes after the jab. She was injected with adrenaline and sent home later with another adrenaline syringe to self-administer if required.

Follow-up showed the woman died of “Sudden Death” within a few days.

Other reports of Death of people with Nickel allergy are listed with Lot numbers.

1F1003A - 70 year-old woman in France after her 3rd dose

She suffered Facial paralysis, left Homonymous Lateral Hemianopsia, Bilateral Miosis, cessation of cerebral circulation, Coma. Cause of death was Ischemic Stroke.

EX6537 - 77 year-old woman in Sweden

She experienced severe pain that moved around her body, hip, legs, back and shoulders.

FC0681 - 58 year-old woman in Switzerland (possible duplicate, see EY3014)

Large intestinal haemorrhage.

ER2659 - 48 year-old woman in Germany

She suffered Nausea, Back pain, Vomiting Blood (Haematemesis), Decreased Appetite, Dysphonia, Fatigue, Tiredness, Exhaustion, metastatic Lung Cancer not visible before the jab.

FA5833 - 51 year-old woman in Germany after her 2nd dose

She died from Pulmonary Embolism and Thrombosis, confirmed by autopsy.

EY3014 - 58 year-old woman in Switzerland

She suffered intestinal Hemorrhage.

Lot unknown - 61 year-old woman in Germany after her 3rd dose

She suffered Angina pectoris, Chills, Diarrhoea, Vomiting and Died of Myocardial Infarction.

Lot unknown - 74 year-old woman in Germany after her 2nd dose

Caught and possibly died of Covid19, doctors found “almost no antibodies”.

Neutrophil Extracellular Traps (NETs)

NETs are networks of extracellular fibers (see illustration above), primarily composed of DNA from neutrophils, histones and proteolytic enzymes, which can have diameters as large as 50 nanometers. Their formation is a defensive response that normally leads to engulfment of microbes and secretion of anti-microbial compounds. Interleukin 8 is one of the chemokines involved.

Here we see both Nickel and Endotoxin (LPS from Escherichia coli 026:B6) increase IL-8 in Human Umbilical Vein Endothelial Cells (HUVECs).

Endotoxins need the cofactor Lymphocyte antigen 96, also known as Myeloid Differentiation factor 2 (MD-2)

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to enter Human Embryonic Kidney (HEK293) cells via the TLR4–human MD2 (hTLR4–hMD2) complex.
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NET formation is promoted by activated platelets and can in turn activate platelets, thus favoring Thrombosis.

Citrullinated Histone 3 (citH3) is a marker for the presence of NETs.

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Myeloperoxidase (MPO) in NETS

Myeloperoxidase (MPO) is a proteolytic, Calcium dependent, enzyme expressed in neutrophil granulocytes that produces hypochlorous acid (HOCl from Hydrogen Peroxide and Chloride ions), as a means of killing bacteria. It is a tetrameric protein incorporating a heme pigment, which causes its green color in secretions rich in neutrophils, such as mucus and sputum. The molecular weight is about 150 kDa.

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MPO also oxidizes tyrosine to tyrosyl radical, which is cytotoxic.

Excess production of MPO can damage host tissue through inflammation and apoptosis.

Vasculitis caused by MPO

Antibodies against MPO are known as Anti-Neutrophil Cytoplasmic Antibodies (ANCAs). Screening for them is a useful diagnostic tool for necrotizing vasculitis.

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MPO is a marker for Chest Pain Heart Damage

The mRNA jabs from Pfizer and Moderna have sent countless thousands of people to seek medical investigation after they suffered Chest Pain.

Elevated Myeloperoxidase levels greatly increase the risk for cardiovascular mortality. MPO alone, or preferably in combination with C-reactive protein are used in diagnosis.

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Toll-Like Receptor 4 initiation of NETosis

In 2007 it was shown that Platelet TLR4 activates NETs to ensnare bacteria in septic blood.

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NETosis and Stroke

NETs form important constituents of cerebral thrombi. DNase 1 has been proposed as a possible prothrombolytic treatment of acute ischemic stroke.

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Tumor-Induced NETosis leads to Metastasis

There is increasing interest in the sudden appearance of Cancers after Pfizer jabs, which might be a result of Metastasis of known or suppressed cancers.

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These have been called "Turbo Cancers".

Bad Batches identified by Pfizer

In a report dated Pfizer identified a very high number of Adverse Reaction reports for some Lot numbers.

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The highest number of cases was for Lot EL1484, one of the lots known to have high Particle count (see following Table).

It is interesting to see also that they used fully automated “visual inspection” to reject vials flowing along the production line.

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Note that Lot EJ 6795 caused the Death of one of the ladies considered above who died of Anaphylactic shock.

What were the particles? I suspect they were Stainless Steel.

1
Geoff Pain PhD
Nickel not Nocebo explains a lot about Placebo
My hypothesis is that Nickel Allergy ( and possibly Chromium Allergy, a topic for a later post) could explain a high proportion of Placebo Adverse Reactions, more than can be explained by Nocebo (psychological effects) or the Sodium and Chloride ions in Saline…
Read more
8 months ago · 14 likes · 3 comments · GeoffPainPhD
2
Geoff Pain PhD
Extreme Toxicity of Endotoxins in Pfizer Jabs
How much Endotoxin is in the Pfizer Jabs? Perhaps we should ask Dr Jordon T Walker, Pfizer executive in charge of corporate strategy for expanding use of mRNA. See the 17 February 2023 update below. Despite US Court order, the document released by Pfizer on its jab testing with Rhesus Macaques using drug product made by BioNTech in Germany and imported to…
Read more
8 months ago · 30 likes · 24 comments · GeoffPainPhD
3
Geoff Pain PhD
Epigenetics of Endotoxin Poisoning from Pfizer Jabs
In earlier articles I discussed the use of Escherichia coli Bacteria in production of the Pfizer jabs and how supertoxic Endotoxins carry through to the vials. Pfizer is legally obliged to measure and report the Endotoxin levels in the jabs but so far has redacted all documents that include actual measured levels using the Horseshoe Crab Blood test…
Read more
7 months ago · 25 likes · GeoffPainPhD
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OpenVAET’s Substack

We mostly publish on our website, https://openvaet.org ; but will release here on Substack French translations of papers of interest & articles which aren't requiring dynamic content.

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De Graff NPJ, et al. 2022. Nickel allergy is associated with a broad spectrum cytokine response. https://onlinelibrary.wiley.com/doi/full/10.1111/cod.14199

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https://en.wikipedia.org/wiki/Lymphocyte_antigen_96

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Schmidt M, et al. 2010. Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. https://www.nature.com/articles/ni.1919

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Vallés J, et al. 2017. Neutrophil extracellular traps are increased in patients with acute ischemic stroke: prognostic significance. https://www.thieme-connect.com/products/ejournals/abstract/10.1160/TH17-02-0130

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https://en.wikipedia.org/wiki/Myeloperoxidase

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Csernok E and Moosig F. 2014. Current and emerging techniques for ANCA detection in vasculitis. https://www.nature.com/articles/nrrheum.2014.78

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Zhang R, et al. 2001. Association Between Myeloperoxidase Levels and Risk of Coronary Artery Disease. https://jamanetwork.com/journals/jama/fullarticle/194339

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Heslop CL, et al. 2010. Myeloperoxidase and C-Reactive Protein Have Combined Utility for Long-Term Prediction of Cardiovascular Mortality After Coronary Angiography. https://www.sciencedirect.com/science/article/pii/S0735109710000835

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Clark SR, et al. 2007. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. https://www.nature.com/articles/nm1565

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Laridaan E, et al. 2017. Neutrophil extracellular traps in ischemic stroke thrombi. https://onlinelibrary.wiley.com/doi/10.1002/ana.24993

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Ducroux C, et al. 2018. Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke. https://www.ahajournals.org/doi/10.1161/STROKEAHA.117.019896

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Cedervall J, et l. 2016. Tumor-Induced NETosis as a Risk Factor for Metastasis and Organ Failure. https://aacrjournals.org/cancerres/article/76/15/4311/613782/Tumor-Induced-NETosis-as-a-Risk-Factor-for

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Pfizer. Covid-19 mRNA (nucleoside modified) Periodic Safety Update Report 1. Reporting Period 19 December 2020 to 18 June 2021.

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Pfizer. Covid-19 Vaccine (BNT162 PF-03702048) BB-IND 19736 Response to 20-Nov-2020 FDA Query. Table 13. Lot Genealogy and Vials Rejected During Visual Inspection for Particles.

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Endotoxins in Pfizer jabs mimic Nickel Allergy

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Endotoxins in Pfizer jabs mimic Nickel Allergy

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GeoffPainPhD
Feb 26Author

I will be expanding this article, adding numerous references in the next day or so.

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Mar 3Liked by GeoffPainPhD

Just came across this study and thought you might appreciate it:

Lustig S, Danenberg HD, Kafri Y, Kobiler D, Ben-Nathan D. Viral neuroinvasion and encephalitis induced by lipopolysaccharide and its mediators. J Exp Med. 1992 Sep 1;176(3):707-12.

"The present study was designed to test the effect of bacterial endotoxin on penetration of viruses into the central nervous system (CNS). As a model we used two neurovirulent viruses that lack neuroinvasive capacity: West Nile virus-25 (WN-25) and neuroadapted Sindbis virus (SVN). ... We suggest that LPS can contribute to virus penetration from the blood into the CNS, a process which turns a mild viral infection into a severe lethal encephalitis. This effect is mediated by soluble factors, and is probably achieved by injury to cerebral microvascular endothelium and modulation of BBB permeability."

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