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You mentioned a 'paywall' but there's a video by "Wong, D" (Dennis Wong) discussing the new testing stuff with AstraZeneca goons which can be accessed by simply putting in a "name" and "email address" (up to you if you provide accurate details or not):

https://www.criver.com/resources/webinar-pi-ms-astrazenecas-lessons-learned

Details from video that might be of interest:

- 1 site used 'Endosafe-MCS' technology, 2 used gel-plate, 7 used plate readers.

- Variable testing with variable sample volumes, variable sensitivity, etc.

- Issues at testing sites; invalid sample rate variable over sites, tests being repeated

- AZ proposed switching to 'Endosafe-MCS' (manufactured by Charles River, the host of the video)

- Complains about 'regulatory burdens' regarding other forms of testing. Puts "water" in quotation marks for some reason.

Other issues noted (~21:00 in the video):

- Nexus audit trail issue: Users able to delete and change entries without permissions

- Sample dilution issue, "software bug"

- Collision risks involving a robot arm (?)

- Damage in transit (somehow a labelling issue?)

- "Faulty Hamilton system at one site"

AZ's justification is "cost" and the poor, poor horseshoe crab (as if pharmaceutical companies ever gave a flying shit about animals), but the buried implication is the inaccuracy and inconsistent testing.

I don't profess to understand endotoxin testing technology, so you will want to review the video yourself to see if there are any obvious red flag I may have missed.

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author

That is great, thanks. What I am looking for is actual measurements of Endotoxin expressed as EU/ml. Did you see any numbers accidentally flashed up?

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I don't think AstraZeneca are going to wilfully convict themselves putting the toxicity levels out there.

I'll have a dig, but just assume I won't find anything for the time being. Unfortunately the EMA leaks only relate to Pfizer.

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