Rapid Liver Failure after Pfizer jabs most likely due to miR-155 upregulation by Endotoxin
Huge numbers of jabbees have suffered Liver Failure within days of getting their mRNA toxic soup. Endotoxin will beat synthetic Spike or LNP components.
In a previous article I showed how Heart Damage caused by mRNA jabs can be explained by the catalytic effects of upregulation of the microRNA molecule known as miR-155.
Liver Failure during the Trial
Pfizer knew from its clinical trial and first 90 days of mass jabbing that severe and Fatal Liver Failure was a clear signal of systemic assault by its product with 70 cases and 5 Deaths.The median onset of the Liver damage was just 3 days!
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Many cases of jab induced Liver Failure are likely hidden under “Sepsis” and “Multi-Organ Failure”.
Pfizer Liver Damage cases have recently been reported here on Substack.
Liver Failure reported by Pfizer after mass Jabbing
Pfizer uses 122 different, often vague, descriptors of Liver Damage under the heading “Hepatobiliary disorders” to deliberately hide tens of thousands of victims.
Selected Examples with case numbers include:
Liver disorder 299
Hepatic cytolysis 226
Hepatic pain 224
Portal vein thrombosis 161
Autoimmune hepatitis 151
Hepatic steatosis 135
Hepatitis acute 106
Liver injury 101
Hepatic failure 97 Acute hepatic failure 34 Chronic hepatic failure 2
Liver transplant rejection 3
and the list goes on and on and on…
Endotoxin in Pfizer jabs catalyzes Liver Failure
In 2007, Endotoxin was shown to cause Fatal Liver Damage in E-miR-155 transgenic mice and their wild-type littermates.
Death was enhanced and hastened by administration of D-Galactosamine.
Rats given Galactosamineshow elevated activities of serum Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), levels of Triglycerides, total Cholesterol, Lipid-peroxidation and reduction in the levels of serum total proteins, albumin and cellular Glutathione S-transferase (GSH). Galactosamine increased the nuclear translocation of NFκB and elevated iNOS protein expression, Tumor Necrosis Factor (TNF-α), Interferon (IFN-γ), Inflammatory Interleukins IL-1β, IL-6, IL-12, IL-18 and decreased anti-inflammatory IL-10 mRNA expressions.
The mechanism of Endotoxin/Galactosamine Liver toxicity involves attack of the Kupffer cellsby Endotoxin attachment to Toll-like receptor 4 (TLR4).
It is known that Tumor Necrosis Factor (TNF-α) enhances the Liver toxicity of miR-155, which is thought to directly target transcript coding for several proteins Fas-Associated Death Domain protein (FADD), IκB kinase ε (IKKε), and the receptor (TNFR superfamily)-interacting serine-threonine kinase 1 (Ripk1).
Eμ-miR-155 transgenic mice produced higher levels of TNF-α when exposed to Endotoxin, promoting the positive feedback loop (Tili 2007).
Wikipedia has good coverage of miR-155 studies for experts to peruse.
Do the mRNA jabs upregulate Galactosamine in Humans, thereby enhancing the Lethality of the Endotoxin miR-155 pathway?
Do the jabs alter the Uridine pathways in Humans?
Are there racial differences in Liver damage by the jabs that might relate to Galactose pathways?
Will Women suffer more Liver damage and Fatality than Men related to Galactosamine involvement in Follicle Stimulating Hormone and Luteinizing Hormone?
I will add material as I delve further, sharing now to prompt awareness and discussion.
Barbara Gehrett, Joseph Gehrett, Chris Flowers and Loree Britt. 2023. Report 51: Liver Adverse Events – Five Deaths Within 20 Days of Pfizer’s mRNA COVID Injection. 50% of Adverse Events Occurred Within Three Days. https://dailyclout.io/report-51-liver-adverse-events
APPENDIX 2.1 Cumulative Number of Case Reports (Serious and Non-Serious, Medically Confirmed and Non Medically-Confirmed) from Post-Marketing Data Sources, Overall, by Sex, Country, Age Groups and in Special Populations and Summary Tabulation by Preferred Term and MedDRA System Organ Class BNT162B2 - ALL Reporting Period: Through 15-APR-2022. FOI-3727.
Esmerina Tili et al. 2007. Modulation of miR-155 and miR-125b Levels following Lipopolysaccharide/TNF-α Stimulation and Their Possible Roles in Regulating the Response to Endotoxin Shock. https://journals.aai.org/jimmunol/article/179/8/5082/111528/Modulation-of-miR-155-and-miR-125b-Levels
Joydeep Das et al. 2012. Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2-NFκB pathways. https://www.sciencedirect.com/science/article/abs/pii/S0041008X12000269
Michaël Maesa, Mathieu Vinkena and Hartmut Jaeschke. 2015. Experimental models of hepatotoxicity related to acute liver failure. https://www.researchgate.net/publication/284810548_Experimental_models_of_hepatotoxicity_related_to_acute_liver_failure