Nickel not Nocebo explains a lot about Placebo

A number of clinical trials of jabs (aka vaccines or other intramuscular injections) show substantial solicited and unsolicited reports of Adverse Reactions. What could cause that?

My hypothesis is that Nickel Allergy ( and possibly Chromium Allergy, a topic for a later post) could explain a high proportion of Placebo Adverse Reactions, more than can be explained by Nocebo (psychological effects) or the Sodium and Chloride ions in Saline.

I wish to test the Hypothesis that Placebo jabs cause a weakened Immune System, leading to higher incidence of Covid19 infection.

This is how Systemic Allergy to Nickel is tested.

Compared with Titanium skin prick as control.

Nocebo

Nocebo Effect describes a situation where a negative outcome occurs due to a Belief that the intervention will cause Harm. I regard that highly unlikely in people who rolled up their sleeves as volunteers. Are any readers aware of Mandatory jab trials where people were coerced into accepting one or more Placebo jabs?

The clinical trials I have seen had 2 subsets of volunteers, one receiving injection of the Test substance and the other an injection of a Saline Placebo.

Given that Nickel and Chromium from the needles used are likely to induce Allergic reaction in a significant percentage of the population, it would be useful to have a 3rd cohort, matched to the rest, but simply observed and receiving neither the Test substance nor Placebo.

Have any such trials been published?

Saline used for Placebo and Diluent

The latest Pfizer clinical trial documents released under Court reveal that there were 2 suppliers of the 0.9% Sodium Chloride (Saline) water used as Diluent in the jabbing experiments.¹ This was also used as Placebo. Hospira (owned by Pfizer and supplier of Tromethamine) was one supplier, the other was German based Fresenius Kabi, which has an interesting history going back centuries² .

Sodium Injection can Cause Pain

I found a paper, still behind a paywall³, demonstrating that injected Saline can indeed increase Pain, although the Wistar Rats used in the study could not complain directly.

The Pain sensation is caused via activation of Transient Receptor Potential Vanilloid Type 1 (TRPV1) channels.

Human skin cell studies show both Sodium and Nickel cause inflammation.⁴

We found that 0.5 M NaCl treatment increased mRNA levels of proinflammatory cytokines such as IL-1α, IL-6 and IL-8 as well as ICAM-1 in NHEK and IL-1α, IL-1β and IL-6 mRNA levels in NHDF. In contrast, H₂O₂ treatment remarkably increased IL-10, GMCSF and ICAM-1 mRNA levels in NHEK, and IL-6 mRNA levels in HMVEC and NHDF. The exposure to haptens did not induce any remarkable increase in mRNA levels of the proinflammatory cytokines in NHEK. But NiCl₂ increased IL-1α, IL-6 and IL-8 mRNA levels in HMVEC, while DNCB increased only their IL-6 mRNA levels. By contrast, SDS stimulated all the cell types to increase at least some of these proinflammatory cytokine mRNA levels. Our present data suggest that each skin component cell participates in inflammatory processes of the skin through its distinctive cytokine production profile when the skin barrier is compromized physically or chemically.

Dinitrochlorobenzene (DNCB), Normal Human Epidermal Keratinocytes (NHEK), Human Microvascular Endothelial Cells (HMVEC) and Normal Human Dermal Fibroblasts (NHDF), Sodium Dodecyl Sulfate (SDS).

Found a very interesting review of Adverse Reactions to Saline Placebo.⁵

Nickel

My friend Openvaet and I have made a very interesting discovery when deep diving VAERS data. A number of jabbees reported experiencing a Metallic, but more specifically, a Nickel Taste after the jab in the arm. Apparently many people have sucked their Nickel coins, jewelry or phone casings and these memories are activated as part of the systemic response.

Here is a SEM picture of syringe needle tip that can be expected to leave some stainless steel in your arm if some of the flakes formed during manufacture break off, presenting a Nickel Hazard.⁶

More great pictures from an elegant study that proved Acupuncture needles could leave metal behind after being jabbed into humans. Numerous cases of Nickel Allergy have been reported after Acupuncture.⁷

Because Tromethamine, used in a number of vaccines including Moderna and Pfizer, is often contaminated up to 15 ppm with Nickel after the catalytic Hydrogenation of its precursor, it would be interesting to determine how little Nickel can cause Anaphylaxis, as has been previously reported with a mitral ring.⁸

Nickel is a Superantigen that can cause Type I hypersensitivity.

A very interesting investigation of the interaction of Nickel with Immunoglobulins.⁹

Nickel is implicated in Autoimmune/autoinflammatory Syndrome Induced by Adjuvants (ASIA)

A 23-year-old woman who developed serial episodes of high fever, extreme fatigue, transient thrombocytopenia, multiple cervical adenopathies, hepatosplenomegaly, anemia, neutropenia, severe proteinuria and urine sediment abnormalities, elevated serum ferritin levels, and transient low positive antinuclear antibodies 1 year after she had a nickel–titanium chin implant.¹⁰

Re-exposure to the same allergen or hapten would lead to the activation of hapten-specific T-cells, which subsequently enter the bloodstream and produce visible signs of hypersensitivity at 48 to 72 hours after allergen or hapten exposure. Human toll-like receptor (TLR) 4 has been shown to play a crucial role in Nickel allergy.¹¹

We found an interesting VAERS report of a lady reacting to her 2nd jab of Moderna in Britain, suffering Adverse Reactions: Arthralgia, Arthritis, Bursitis, Chills, Decreased appetite, Diarrhoea, Nausea, Neuralgia, Pyrexia, SARS-CoV-2 test (was negative), Sciatica.

She had previously reacted to the Nickel in alloy syringe needle.

Anaphylaxis Pfizer Death with Nickel Allergy

Anaphylaxis Sudden Death of a 44 year-old woman was reported in VAERS after a Pfizer jab with Lot EJ6797 in January 2021. The Nickel allergy was related to past exposure to the metal in cosmetics.

Endotoxin and Nickel effects on Ectosomes

In 2015 Turbica and coworkers studies the effects of Nickel in Acute Contact Dermatitis and used Endotoxin as a comparator.¹²

Figure 4 caption reads:

PLB-Ect modulate NiSO4-induced proinflammatory cytokine production by moDCs at the mRNA and protein levels. (A) Expression of cytokine mRNA. Immature moDCs were preincubated for 30 min with PLB-Ect or medium alone and then for 4 h with medium alone, LPS (control stimulus), or NiSO4. IL-1b, IL-6, IL-12p40, and TNF-a mRNAs were quantified by real-time RT-PCR. Results were normalized to nonstimulated. The results of 6 independent experiments are shown. *P , 0.05. (B) Cytokine release in moDC supernatants. Immature moDCs were preincubated for 30 min with PLB-Ect or medium alone and then for 18 h with medium alone, LPS (control stimulus), or NiSO4. IL-6 and IL-12p70 levels are expressed in pg/ml. The results of 6 independent experiments are shown. *P , 0.05.

They also studied stimulated cell markers including PDL-1 (Programmed Death-Ligand 1).

Figure 3. PLB-Ect modulate the expression of key surface markers of moDC maturation. moDCs were preincubated for 30 min with PLB-Ect or medium alone and then for 18 h with medium alone [nonstimulated (NS)], LPS (control stimulus), or NiSO4. moDCs were then collected, washed, and analyzed by flow cytometry for membrane expression of CD40, CD80, CD83, CD86, HLA-DR, and PDL-1. (A) Representative histograms of CD40 expression on nonstimulated DCs (left) and NiSO4-induced, stimulated DCs (right), without PLB-Ect (solid lines) or with PLB-Ect (dotted lines). Mean of fluorescence is indicated for each histogram. Isotype controls are in gray. (B)

From my earlier studies, all chemical sensitizers are a Cancer risk.

Update list of VAERS reports of Metallic Taste.¹³

1. https://vaccines.shinyapps.io/abstractor/

2. https://www.bloomberg.com/opinion/articles/2018-08-13/nebraska-death-penalty-fresenius-kabi-wants-out-of-pr-mess

3. Wang Y and Wang DH. 2007. Increased depressor response to N-arachidonoyl-dopamine during high salt intake: role of the TRPV1 receptor. https://journals.lww.com/jhypertension/abstract/2007/12000/increased_depressor_response_to.11.aspx

4. Terunuma A, et al. Cytokine mRNA profiles in cultured human skin component cells exposed to various chemicals: a simulation model of epicutaneous stimuli induced by skin barrier perturbation in comparison with that due to exposure to haptens or irritant. https://www.jdsjournal.com/article/S0923-1811(00)00165-1/fulltext

5. Ricke DO. 2023. Etiology Model for Clinical Studies’ Intramuscular Injection of Saline Solution Control Driving Innate Immune Response Associated Adverse Events in Volunteers. https://www.innovationforever.com/article.JMBDD20220178

6. http://murry-gans.blogspot.com/2013/05/how-sharp-is-new-hypodermic-needle.html

7. https://www.researchgate.net/publication/260168905_Examination_of_Surface_Conditions_and_Other_Physical_Properties_of_Commonly_Used_Stainless_Steel_Acupuncture_Needle

8. https://www.sciencedirect.com/science/article/abs/pii/S0003497517316260

9. https://www.frontiersin.org/articles/10.3389/fimmu.2021.676048/full

10. https://www.researchgate.net/publication/257801970_Autoimmunity_in_Connection_with_a_Metal_Implant_A_Case_of_AutoimmuneAutoinflammatory_Syndrome_Induced_by_Adjuvants

11. https://www.researchgate.net/publication/292946913_Molecular_Mechanisms_of_Nickel_Allergy

12. Turbica I, et al. 2015. Ectosomes from neutrophil-like cells down-regulate nickel-induced dendritic cell maturation and promote Th2 polarization. https://academic.oup.com/jleukbio/article-abstract/97/4/737/6975080

13. https://www.scribd.com/document/511041883/VAERS-Adverse-Events-After-Covid-Vaccine-Metallic